Difference between revisions of "LINP1"
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==Annotated Information== | ==Annotated Information== | ||
| − | [[File:Expression and genomic alteration of LINP1 in breast cancer.jpg|right|thumb| | + | [[File:Expression and genomic alteration of LINP1 in breast cancer.jpg|right|thumb|300px|'''Expression and genomic alteration of LINP1 in breast cancer'''<ref name="ref1" />]] |
| − | [[File:LINP1 RNA associates with Ku80 and DNA-PKcs.jpg|right|thumb| | + | [[File:LINP1 RNA associates with Ku80 and DNA-PKcs.jpg|right|thumb|300px|'''LINP1 RNA associates with Ku80 and DNA-PKcs'''<ref name="ref1" />]] |
| − | [[File:LINP1 serves as a modular scaffold in the NHEJ pathway.jpg|right|thumb| | + | [[File:LINP1 serves as a modular scaffold in the NHEJ pathway.jpg|right|thumb|300px|'''LINP1 serves as a modular scaffold in the NHEJ pathway'''<ref name="ref1" />]] |
===Approved Symbol=== | ===Approved Symbol=== | ||
LINP1 (lncRNA in non-homologous end joining pathway 10 | LINP1 (lncRNA in non-homologous end joining pathway 10 | ||
Latest revision as of 14:23, 22 October 2017
Contents
Annotated Information
Expression and genomic alteration of LINP1 in breast cancer[1]
LINP1 RNA associates with Ku80 and DNA-PKcs[1]
LINP1 serves as a modular scaffold in the NHEJ pathway[1]
Approved Symbol
LINP1 (lncRNA in non-homologous end joining pathway 10
Chromosome
10p14
RefSeq ID
NR_138480
Expression
Compared with the non-basal lines, LINP1 has significantly higher expression level. [1]
Function
LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. [1] Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.[1]
Regulation
LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. [1]
Labs working on this lncRNA
- Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
