LINC02599

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LINC02599, long intergenic non-protein coding RNA 2599 with a critical role in TGF-β-induced EMT.

Annotated Information

Name

LINC02599: long intergenic non-protein coding RNA 2599 (HGNC:53931)

Alias

AC026904.1

Characteristics

Confocal RNA-FISH images showing subcellular localization of UCA1 and AC026904.1 in MCF7 cells underwent EMT. [1].

LINC02599 is a lncRNA gene with a little or no protein coding potential located at chromosomal location 8q11.21. RNA-FISH data showed that AC026904.1 was highly enriched in the nucleus. It could used as novel biomarkers and therapeutic targets for metastatic breast cancer. [1]

Function

This lncRNA functions as an enhancer RNA (eRNA) to activate Slug expression at both transcriptional and post-transcriptional levels in cis in breast cancer. Because AC026904.1 is a lncRNA highly enriched in the nucleus it may act to regulate its neighboring genes. [1]

Regulation

LINC02599 is regulated by TGF-β. It is upregulated through TGF-β/Smad pathway in breast cancer. [1]

Expression

Relative RNA levels of AC026904.1 in cytoplasmic or nuclear RNA fraction of MCF7 cells treated with TGF-β1. [1].

LINC02599 is highly expressed in metastatic breast cancer and closely associated with poor prognosis.[1]

Disease

Breast cancer [1]

Labs working on this lncRNA

  • State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
  • Department of Immunology, Fourth Military Medical University, Xi'an, China
  • Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
  • Department of Oncology, No. 88 Hospital of PLA, Tai'an, China
  • Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an, China

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Li G-Y, Wang W, Sun J-Y, Xin B, Zhang X, Wang T et al. Long non-coding RNAs AC026904.1 and UCA1: a "one-two punch" for TGF-β-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer[J]. Theranostics. 2018, 8(10):2846-2861.

Sequence

>ENST00000430626.1 Homo sapiens lincRNA LINC02599 cDNA

000001 AGCCCACGTT CACTATTGAA CACAACGGAA GGGGGAATTA TTGTGCTTCT TGCTTTGATT CCCAAGCTGG TGTTGTCTGA 000080
000081 GCCTGTCTGG CATGTGCTCT GCCTGCCCTG ACTTCTGACC CCAGGAGGAG CATTCAAGGA GCCAAGGAAT GGGTCCAGGC 000160
000161 ATTGTGCTAG TATCTAGCCA TGGCAAGATG CTAGATCTAA CCATGACGAG AGCAGCTAAG ATCGGACTGT ACCTGAGTGA 000240
000241 GCCCATTGAA TCCTCCACCA GCACCACACG GGGTTTCTAT TGTTTGTCTC AGCTGCAGCA ACATAATATG AGACAAGGGC 000320
000321 CAAGAACTGC AGAACTGTGC ACGGTGTTTA GAAGAGGCTG CGAGCTGCTG CTCTGCAGAG TTGGGAGGTG CTTTCGGGCT 000400
000401 CTGCAGGCTC CCTGCAGGCC CTTGCTGACT GTCCATGGCC TGCACCTGCC CTACCTGCTG AGCTGCCCCA TCAGCTGCTC 000480
000481 CTGGCTGTGG TTTCCTGAGG GGTCCCGTCT GCATCGGCTG CCCTGTGTCC TGACACTATG GTGGGTTTGC AAGTGGCAAA 000560
000561 GTCCAGGGAA GGAGACTGGG GAGCATGGCC ATGGGTCATC CGGGGGGCAC GGAGGGTTCC GGCTCCCGCC CAGGTCCACC 000640
000641 TGCTTCATCA GCAGTGGTCA CCAAGATTGC ATAACCAGGA CGATGACAAC GCTGAGAGCT CTGTTGCAGT TAAAGACTTA 000720
000721 AGAACAACTT GTGCCTGCTG ACTAATACAT TTTATCACCC AGGCAGCGTC AGGACTCTGA GAGCCTCTCA CATGCTGCTG 000800
000801 TCATCTGAGC GAGACCTCAA GATTTGTCAT CGAGCAGGCT GACCCTTGCC TGAATGGACC TCACATTCTT GAGGCAGGGA 000880
000881 GAGATCTGCA ATCAGCATGA TCGATCAGCG ATTTTCATAA GACGTTAGAA GTCATCAGAG CTTAGGAAAC AGGGTGAGGA 000960
000961 AGTAGGGGAG GAGCCGGAAG GGCCCCCATT TAAAACAAGG TGGCCAGGAT AGGCCTCTCT GTAGGGGTGA CATTGAAGAA 001040
001041 ATGGTGGGAG AGGGTGTGAG GTGCACATCT CTGAGGGCAG AGTGTTCTGG AGACAGGAAA CCATCTGTGC AAAGGCCCTG 001120
001121 TGGTGAGAGG GTGCTAGGAG CTAGCAAGCC CAGTCTACTC AACACAGCCA TCATTTTAAA ACCTCGGTGA GCCCTGTCCC 001200
001201 TTATCTTCTG AACCCCCTCC CACAGAAGCG GATGTCACTG AGAGTGAAAG CTGCAGTGTA GGGTGGCCTC CTCTGCACAC 001280
001281 CGGCCCTGGC CCTCTGACCT CTTCTACCCC ATGATGGTCC CCTGTCAGCT GGGTCTAGAG TGGACCGTCG GGGCAGACCT 001360
001361 GGAAGGGGAA GGCTGTCAAG TTCCTGCTCC CCTGTGACAT ACAGCAACAC ATTTGTTTCC CCCTGGATTC TGGGGATCAG 001440
001441 CAACATGTGC GGGTGGGGGC AGGGCAGTCC TGCTGCTCTG GGATGGGCTG CCCCCTCAGG GAGGACTGGC CAGCTGGGTG 001520
001521 GCTCTGCTCC TGGAGAGTGA CCGGCCATTT GCTGGGTGGA TGGGGTGACT GTCCTGAGAG CTTGGCACCA CCAGAAGTGT 001600
001601 AGTCCACGCA GCCCTTCACA GGTGGCTCAG GGTGCCCAGC GGGGCAAGAG GTGGCCCTCA AGCTAAGCTT GAGCTTAAGC 001680
001681 CTAAGCCTAA GCTTGCCACG CTTGGGCTAG GATGCCAAGT CTCCATGCTG GCTGCTGGTC ACAGCTCTGT CCCTGTGGGA 001760
001761 GAAGACGACT GAAGCCTGGC CAGGCTGGGC CATCTCCCCA GCAGCCACCA GGGCTTGCTG TGAGATGTGG GAGCCATGCT 001840
001841 AGGGTCCTGC CCCGGGGATG TTGGTAGGCA TGGTGGGAAG CAGTGCAATT ATGGATATTT TCTGGAGATA ATCATCAACA 001920
001921 GGATTTGCTG ATGGAATGGA CCTGGAATAC AAGAAGAAAA GGAATCAAGG ATGGCTCTGA GGTTCGGGGC TTGAGCAACT 002000
002001 TGGATGGGGG TGCTGCTGAG TCAGGTGGGA GGGGAGCAGG CTCAGGGGAT GCGGACTCCA TTTGAAGTGG CCGCGTTGGA 002080
002081 GATGTCTGTG GACATCCACG TGAAATGCTG AGTGGCCAGC TGGACATGTG GATCT