Difference between revisions of "LINC02599"

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Revision as of 06:25, 17 December 2018

LINC02599, long intergenic non-protein coding RNA 2599 with a critical role in TGF-β-induced EMT.

Annotated Information

Name

LINC02599: long intergenic non-protein coding RNA 2599 (HGNC:53931)

Alias

AC026904.1

Characteristics

LINC02599 is a lncRNA gene with a little or no protein coding potential located at chromosomal location 8q11.21. RNA-FISH data showed that AC026904.1 was highly enriched in the nucleus. It could used as novel biomarkers and therapeutic targets for metastatic breast cancer. [1]


Function

This lncRNA functions as an enhancer RNA (eRNA) to activate Slug expression at both transcriptional and post-transcriptional levels in cis in breast cancer. Because AC026904.1 is a lncRNA highly enriched in the nucleus it may act to regulate its neighboring genes. [1]


Regulation

LINC02599 is regulated by TGF-β. It is upregulated through TGF-β/Smad pathway in breast cancer. [1]


Expression

LINC02599 is highly expressed in metastatic breast cancer and closely associated with poor prognosis.[1]


Disease

Breast cancer [1]


Labs working on this lncRNA

  • State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
  • Department of Immunology, Fourth Military Medical University, Xi'an, China
  • Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
  • Department of Oncology, No. 88 Hospital of PLA, Tai'an, China
  • Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an, China

References

  1. 1.0 1.1 1.2 1.3 1.4 Li G-Y, Wang W, Sun J-Y, Xin B, Zhang X, Wang T et al. Long non-coding RNAs AC026904.1 and UCA1: a "one-two punch" for TGF-β-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer[J]. Theranostics. 2018, 8(10):2846-2861.

Sequence