Difference between revisions of "LINC02596"

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Latest revision as of 11:16, 26 December 2018

LINC02596, a long non-protein coding RNA differentially expressed in postmenopausal osteoporosis (PMOP).

Annotated Information

Name

LINC02596: long intergenic non-protein coding RNA 2596 (HGNC:53948)

Alias

LOC105376834 (HGNC:53948)

Characteristics

LINC02596 is long non-protein coding RNA located at chromosome position 1p36.12.[1]

Function

LOC105376834 may regulate the expression of ALPL by a cis-effect. ALPL is an osteoblast marker and is reported to be closely associated with the development of osteoporosis. Downregulated ALPL can reflect decreased activity of osteoblasts, bone formation and extracellular matrix mineralization. As ALPL is a nearby co-expressed DEmRNA of LOC105376834, it was hypothesized that LOC105376834 may be involved in PMOP by cis-regulating the expression of ALPL and the pathway of osteoclast differentiation. [1]

Regulation

This lncRNA was downregulated in PMOP. [1]

Expression

LOC105376834 is coexpressed with nearby ALPL.[1]

Disease

Postmenopausal osteoporosis (PMOP) [1]

Labs working on this lncRNA

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China

References

  1. 1.0 1.1 1.2 1.3 1.4 Fei Q, Bai X, Lin J, Meng H, Yang Y & Guo A. Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis[J]. International journal of molecular medicine. 2018, 41(6):3537-3550.

Sequence

>ENST00000457706.1, Homo sapiens lncRNA LINC02596 cDNA antisense

000001 GCCTGTGTGG CTTCCTCTGA GCCTCGCAGG GACTCTGCCT TGATCACAGC GCCAGGGCCT TTTCTGGCTT CTCAGCAGTC 000080
000081 TGTGTGAACC TTCAGATGGG GTGGGCACAC GTGGCACCCC CAGCCAAGCA GGGGACGGGC CGGACTCGGT CCTCCAGTGT 000160
000161 CACCTCTCCC TCCTGCCACT GGAACCGAGG CTTAGAATCA CTGAGGCGGT GGGAACATAG CTGTGGGCAC AAGAGTGGAC 000240
000241 ATTTCTACGG CGTTCCCTGC TGACCAGGCG CTGTTCTCAC GTGCCTCACA GCACACATTA ACTCATCTTC CCCGCAACCA 000320
000321 GCCCTGGAGG GCAGGGACTG TGATTTTCCC CATTTTACAG ATGAAGAAAC AGAAGCAGAA ATGTTTAAAC TTATGGGAAG 000400
000401 ATACACCACT AACAAGGGCT GGAGCCAGGA CTCTAGCCAT GCAGTGTGGC TGCAGAGTAC AGGATTTTAA TCACCCGTTG 000480
000481 CATCCTCTGG CGTCGGGCAG GGCTGGACTT CAGGCTGGGT TTTCCCCGTT CCCAGCTGCA CCCACGTCGT GTCTCCTCCT 000560
000561 GGAGTCTAAG TTTCCTGTGC TGTGACTGCA GGCGGAGAGG AGGGCCCAAC GTCTAGGGGA TTTCATGCTG CATCTAGAAG 000640
000641 CCAAAACGCT GACACCCCTT GAAAAGGAGG GCTGGGAACT GAGATGATTG ACGCCCCAAG GGGAAGCGGG CGCTTCCCAG 000720
000721 AACAGCCTCG GCATGACCTG GACATGGAGC CAGGCGGCTG CTCCTTGCCC AACCCATGGG GGCCTTGCAA TGATTAATAA 000800
000801 TAATAATGAT GATGATAATG G