LINC01060

LINC01060, induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover

Annotated Information

Approved Symbol

LINC01060

Approved Name

LINC01060: long intergenic non-protein coding RNA 1060

Characteristics

LINC01060 belongs to the class of long non-coding RNA located on chromosome 4q35.2 .

Function

LINC01060 plays a key role in suppressing pancreatic cancer invasion and metastasis . LINC01060 inhibits vinculin and increases FAK and paxillin phosphorylation . LINC01060 promotes focal adhesion turnover and enhancing cell motility .

Regulation

NA

Diseases

• Pancreatic cancer .

Expression

LINC01060 showed the lowest expression in pancreatic cancer tissues compared with normal pancreatic tissues .

Labs working on this lncRNA

• Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

References

Sequence

>gi|401164|ref|NR_033869.1|Homo sapiens long intergenic non-protein coding RNA 1060 (LINC01060), long non-coding RNA

000001 GATAGACATC TGGGCAAGTC AACAGGAAGG TGGATATCCA AATCTCTCTC TTCGCAATGA GTTTCCAGTT AGATGGAGGA 000080
000081 GAGAGTAATA AAACACAGAG CTGAGATTCC TGACTTCACA GATCCCTGAG GAGATGTTTA CTAAAGGGAA TCTTCTGGTC 000160
000161 ACTGTTACCT TCCTCCGTAC TTACCTGCCT CATGGATAAC ACTGAAGAAT GCAGTTTACT TACATCTTTT TCTGTTTGAC 000240
000241 AGAAGACAGT TATTAGAACC CGAAAGGAAG AAGCTATACG ACTGGGGACA CATGTCTTAG AAGCACACTC ATTAGATAAA 000320
000321 GTGTCGCATA CTCTTTGATA AGTGACTCAG AACACCCGTG TCCTTCCCAA CATTGGATGC AATGCTAAAG ACATGATGTT 000400
000401 GCTCCTGCTG GACCACACCT TGAAGGAATT GCCTACCCCA CCTCACCTCC AAAATTAAAG TCTTTCGTTT TGACAAAAGT 000480
000481 TAA