Difference between revisions of "LINC00894"
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Revision as of 05:34, 24 December 2018
LINC00894, long intergenic non-protein coding RNA 894 contributes to inhibit tamoxifen resistance (TamR) in breast cancer.
Contents
Annotated Information
Name
LINC00894: long intergenic non-protein coding RNA 894 (HGNC:48579)
Characteristics
LINC00894 is a long non protein coding RNA gene located at chromosome Xq28. LINC00894-002 exhibits the most sophisticated network pattern and is the most downregulated lncRNA in MCF-7/TamR cells. [1]
Function
LINC00894 inhibits TamR through the miR-200-TGF-β2-ZEB1 signaling pathway. [1]
Regulation
LINC00894-002 is directly upregulated by ERα.[1]
Expression
LINC00894 expression level is lower in tamoxifen resistance MCF-7/TamR cells compared to the sensitive cells. Knocking down LINC00894-002 downregulates expression of miR-200a-3p and miR-200b-3p, upregulates the expression of TGF-β2 and ZEB1, and finally contributes to TamR.[1]
Disease
Breast Cancer [1]
Labs working on this lncRNA
- Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.
- College of Liren, Yanshan University, 066004 Qinhuangdao, China.
- Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.
- Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China. wangxt11@ustc.edu.cn
- CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Hefei, 230026, China
