Approved symbol: LINC00339
Approved name: long intergenic non-protein coding RNA 339
HGNC ID: HGNC:25011
Previous symbols: NCRNA00339
Previous names: non-protein coding RNA 339
Alias symbols: HSPC157
RefSeq ID: NR_109762
Ensembl ID: ENSG00000218510
LncBook ID: HSALNT0002923
~330 nt in vertebrates*. Transcribed by RNAP III, GC-rich sequence forming conserved secondary structures (especially 3' and 5' stem-loop motifs).
The 7SK gene is located on chromosome 6, and chromosome 6 is the sole human chromosome that produces 7SK RNA ((Driscoll 1994))
7SK RNA is capped at its 5' end by BCDIN3, a specific methylase methylphosphate capping enzyme (MePCE) ((Jeronimo 2007)).
RNAP II was recently found to bind near 7SK promoter, as well as many other known Pol III genes, suggesting that RNAP II may also play a role in regulating their transcription ((Raha 2010)).
Nuclear, highly abundant (one of the most abundant small RNAs in vertebrate cells), first isolated from HeLa nuclear extracts, but ubiquitously expressed.
RNA sequencing from 11 humans tissues confirmed ubiquitous high expression of 7SK with expression in some tissues being higher than any mRNA ((Castle 2010)).
Intergenic SNP (rs6426749) at 1p36.12 acts as a strong long-range allele-specific enhancer to regulate the expression of LINC00339.
LINC00339 might influence bone metabolism by modulating expression of CDC42, which is an important gene involved in bone metabolism.
Please input evolution information here.
Labs working on this lncRNA
- Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
- Chen XF, Zhu DL, Yang M, et al. An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation[J]. Am J Hum Genet, 2018, 102: 776-793.
>gi|564473412|ref|NR_109761.1| Homo sapiens long intergenic non-protein coding RNA 339 (LINC00339), transcript variant 4, long non-coding RNA