LCAL1

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Annotated Information

Approved Symbol

LCAL1

Approved Name

lung cancer associated lncRNA 1

Synonyms

onco-lncRNA-27

Chromosome

6q14.1

RefSeq ID

NR_130915

pubmed IDs

25116943, 25864709

Disease

  • Lung cancer

Characteristic

LCAL1 is enriched in the nucleus and located on chromosome 6q14.1 and produces a three-exon transcript.[1]

Expression

Integration of exome sequencing data reveals that expression levels of many LCALs have significant associations with the mutational status of key oncogenes in lung cancer.Functional validation, using both knockdown and overexpression, shows that the most differentially expressed lncRNA, LCAL1, plays a role in cellular proliferation.[1]

Function

LCAL1 has been validated and determined to regulate cellular proliferation in vitro.[1]

Evolution

LCAL1 lacks strong base pair conservation, however, LCAL1 appears to be evolutionarily conserved amongst primates, suggesting a more recent evolution.[1]

Labs working on this lncRNA

  • Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA [1].

References

  1. 1.0 1.1 1.2 1.3 1.4 White, N. M., C. R. Cabanski, J. M. Silva-Fisher, H. X. Dang, R. Govindan, and C. A. Maher. "Transcriptome Sequencing Reveals Altered Long Intergenic Non-Coding Rnas in Lung Cancer." Genome Biol 15, no. 8 (2014): 429.

Sequence

>gi|756141055|ref|NR_130915.1| Homo sapiens lung cancer associated lncRNA 1 (LCAL1), long non-coding RNA

000001 ACTATTGTCT GTAAAAGGTA CAACTACCTT GCTGATGCTG TACATATGGC TCACTTGTGC CCAGAGAGAG AATAAAGCCA 000080
000081 TGTCGAAACT ATCTACGATT CCTTGAGTGT TTTTCCAGCT ACCTGCCACT TGCCCACCCA CTCCCCTCAG ATCTCAGTTA 000160
000161 GAACATGACA ATTGGGCTCA TGAACAGGAT CCTGAGTGGT TGCAGGTGAA CAAGCAGTTG GCACAAGGGC AAAGTGATCA 000240
000241 CATCCTGATT GAGTGGCTAT GGACAGCCAT ACAGACTGTG TGGAACAACG CTGGTGAAAT ACCCAAACCA TTTAGAAGCA 000320
000321 GTAATGCCTC TCTTGCCTGG GACTGGGATG GTGTGGCTGA GACTGCCTTA CTGGCAGCCA GGTGCGCTAT TCAGCAGCCA 000400
000401 CAAGCCCTAC AAGTAATTAA CCAGGGGCAC CTGTTTGAGC TGGAGGTGCA TGTGGCCACA GACGGTTTTG GTTGAGGCTT 000480
000481 GTGGCAATGC ACAGAGCGCC TAAGAATGCC AGTAGGCTTT TGGTCCCAAC TATGGAAAGG AGCTGAACTC CGGTATTCAT 000560
000561 TGATAGAGAA ACAGCTAGCA GCTGTATATG CTGGCCTTCG GGCTCATGAG AGCATGACAG GACAGGCTGC AGTCATCATA 000640
000641 TGGACAACTT ACCCAATAAC AGGATGGATG CGTCTATGTG TAATGACCAC CTGGAGTGGG ATAGCACAGA TGTCCACTTT 000720
000721 GGCAAAATGG GGCAACTCCT TGCAGCAGTG GAGTAAGCTG AGTACAAGTC CCATAGCAGC AGAGTTGCAA GAGGTCTTGG 000800
000801 GACGTGTAGT CCTAATGCAA GATAAGGCCA TGCGGCCTGA GGCACCCCTA GATCCTGAGT CTTCACCATT TAAGGAAGGG 000880
000881 CATCCCAGGA TTCCTGAGGG GGCATGGTAC ACAGTAGATG AGGTGCTACT GCTGCCTGGA CCACTGTTGC AGTCCAACCT 000960
000961 AGTACTGACA CCATATGGTT TGAAACTGGG TGCGGACAAA GTAGCCAATG GGCTGAACTC AGAGCAGTGT GGATGGTGAT 001040
001041 CACCAAGGAG GTGACACCTG TGGTAATCTG TACTGATAGC TGGGCAGTCT ACTGAGGCTT AACCTTGTGG TTAACTACTT 001120
001121 GGAAAATACA GAATTGGCTA GTGAGCCACA GACCCATTTG AGGCCAAGCC ATATGGCAAG ACCTTTGGGA AATAGGTCAT 001200
001201 CAAAAAGAGG TAACTATTTA TCATGTGTCA GGCCATATGC CTTTGGCCAC CCCTAGTAAT GATGAGGCAG ATGCCTTGGC 001280
001281 TAAGGTCAGA TGGTCAGAGT CAGCACCAAC ACAAGATGTG ACCTTGTGGC TACACCGGAA ACTGGGACAT GCAGGGGGTA 001360
001361 AACTGATGCA ACAATTCAAT AAGTGTTGGG GTCTGTCCCT TCCCAAGCAA GACATTTGTG AGGCTTGTCA GAAATGCCTG 001440
001441 GCATGTGTTC AGACATATCC TAAAAAGAGG CAGCTGCCCG GTGTTATACA ACAAGTAACA ATAGGGTGAG TGCCCTTGAC 001520
001521 CAGGTGGGAA GTAGACTACA TCGGGCCGCT GCCAAAGTCG CGAGGGTATA CGCATGCACT AACGGCTGTA GACATGGCCA 001600
001601 CAGGCCTGTT GTTCACCTAC CCTTGCAGGG TGGCCAACCA ACAGAACACC ATCCAGGCCC TGCAACACTT ATGTTCCCTG 001680
001681 TATGGTTGTC CTCTGGCCAT TGAGAGTGAT AGGGGAACAC ATTTCACTGG ACAACAGGTA CAATGATGGG CACAGCAAAT 001760
001761 GGACATAAAG TGGGGATTCC ATGTGCCATA CAGCCCACAA GCTGAGGTAT TATTGAATGA TATAATGGGA TCTTGAAGAA 001840
001841 TGGATTACGC TTGCATGTCA AACCCCTGTC TTTGCGGAGC TGGAGTTCCA GGCTGGACCT GGTGCTCCAA ACCTTAAATG 001920
001921 AATGGCCACA GAAAGGTGGC CCGGCCCCAG TGGAGGCTTT GTTTCACTAG GCCACCACCC CCATTCAATT GGAGATACAT 002000
002001 ACCAAGGATG ACCTCCTCCG ATCAGGTATG GGGACAAATG GTAACCTGTT GTTGCCTGCC CCAACAACCC TGAAGGCAGG 002080
002081 GGAACAGAAA ACCTGGCTGT GGCCATGGAC CCTCCAAGCT CTCCACTGCT GGTGGTTGGC CATCATAGCT CCCTGTGGGG 002160
002161 AGGGCCTACA GTATGACTTG CATGTCACTT TTTGAGTGTT CAATACATGG CTTCCAAGGT TGACTGTTTG TAGAGGAACA 002240
002241 GCCAGGGAAG GAGCCCTCCT CTGAGGGACA TATGTACTAT CTGATGGGCC TATTATGAGC TACGCTGTGA CTTTGGCATG 002320
002321 GATACAGGAT TCAAAGGAAC CATGGAGATT TGAGAAGGTG TGGTACCATC ACCCAGGGCA AAAGCCCTTG GTGGCTGCAT 002400
002401 TGTTATCCAG GGATGGAAAG TTAGCCTATA TTTTGCCTGA GGGATGTGAT TTACCTCTGT TAGTACCTGT GCCTGCTCTG 002480
002481 TCATTTCAAC CGTAGGTTAA CATGCTCCAA TTGCATTGTG GACTGACCCC ACACCTATGC TGAGGTGACC AATGTTTCCA 002560
002561 ACTGTTGGAC CTGCACTGCC TTTCCAGCAG CAGCTGCAGA CAGCTTTCCC TGACACATAC ATCCCGTGTC TGCAGAGAAC 002640
002641 TGGACATGCC TGGAGACTTG AGATCCCATG GCTGATGCCT GGAACACAAT GTGGCAAGCT TTGGACAAAG GACACAGCAA 002720
002721 GACCCATGGC TGGACCGTAG CATTCGTGAT GAGTGGGGCT GGCTAGTAGG GGAACATGTA GTAGCCCAAG CCCAGGCATT 002800
002801 GCAGTGCACA GAGCAACATT GGGGTAACAG GATGGGTACC TGTCACGGCC TGTGCAAACA TAACATGTGT CACCACACTG 002880
002881 AAGGTATGGT GGAACAAGTG GCCTCACCAA GGTCGGACCC CAATGGACTT TTTGCCTCTT GGGAGCTTAT GGGTCTATGA 002960
002961 GGACACAGTA GCCTTTCCTA TCAGCAAACT GGAGTGGATG TTGTATCTGG GGGTGGCCTT ATGTACCTGC TACTGTTCTC 003040
003041 CCCACATTGC CCAGATGCCT GTATAACTGG GAGGCACTGT GCTCTCAGTT TTTGCGAATG TGATGAGCCC CCTGGTGTTT 003120
003121 CTACCCTTTG GCAATGACTA TCCCTGGAGC AGGTGTCAAA ACTGTAGAAG CACAATTTAC TGCTCTTGCG GAGCACACCG 003200
003201 CTCAGGCTCT GAATTACACC TGAGTGTCCC TCCTCCTGTT AATGAATGAG GTTGATCAGA TCAAAAAGTG GTGTTGCAAA 003280
003281 ACCAAGTGGC CTTAGACATA ACTGCTGCCC AAGGAGCCAC CTGTGCCCTT TTAGGAACAC AATGTTGTAC CTTATCCCTG 003360
003361 ACAATCAGCA GAACATAACA GCAGCCCTGC AAAGGGGTCT TCCAGGAGAT TAAGGTGACT GAGAGCCTCA CTGTCAACCC 003440
003441 CCTGCAGAGA TGGTGAGCAT CCCTAGGTTC TGGCGTACAT TGGGCCCTAA TAGTCATAAG TATCATAGCT GAGATCCTAG 003520
003521 TAGTGAGCTG TTGCTCTCTG TATTGTTGTT GTGGGTTATG GACTCAGGGC TCCGCCATAT AGGCATGTGT CCCTGCCTGG 003600
003601 AGGACGCCCT CAGCCTAGGG GGTGTAGTGT AAGGGAAATG GCTGTGCTTT AGTCAGGAGT AGGCTGAGGC AGCCTTCTGG 003680
003681 TGCAGCATGA CTCAGTGGGT TTGGAGTGCA AGCACACAAC CTTGCTCGTT ATGTAACCAC ACCACATGAG GCACATTAGG 003760
003761 TAACAACTCA CATGAGCTCG TGTTTGGCTC AGAGCCACTA TTGTCTGTAA AAGGTATACC TTGCTGATGC TGCACATATG 003840
003841 GCTCGCTTGT GCCCAGAGAG AGAGTAAAGC CATGTTGAAA CTGTC