KRTAP5-AS1

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KRTAP5-AS1 acts as an oncogene in vitro through binding miR-596 and miR-3620-3p.

Annotated Information

Name

KRTAP5-AS1: KRTAP5-1/KRTAP5-2 antisense RNA 1 [1].


Characteristics

KRTAP5-AS1 is two exon transcript of 2265 bp long non-coding RNA, located on chromosome chr11p15.5 and has five predicted miR-3620-3p targeting sites and five predicted miR-596 targeting sites [1].

Function

The mechanism graph of the regulatory network and function of CLDN4. CLDN4 could promote proliferation, metastasis or EMT processes of GC, which could be inhibited by miR-596, miR-3620-3p and enhanced by KRTAP5-AS1, lncRNA-TUBB2A as ceRNAs. [1]

KRTAP5-AS1 serve as a competing endogenous RNAs (ceRNAs) for miR-596 and miR-3620-3p and regulate the expression of CLDN4, a critical member of the claudin family, has been observed to alter expression patterns in various types of carcinomas including gastric cancer, pancreatic cancer, and ovarian cancer [1].

KRTAP5-AS1 and lncRNA-TUBB2A enhance the proliferative and invasive capacity of GC cells in vitro [1].

Expression

KRTAP5-AS1 is overexpressed in gastric cancer (GC) [1].

Regulation

Please input information here.

Diseases

  • Gastric cancer (GC) [1]

Labs working on this lncRNA

  • Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City 110001 China.[1]
  • Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 USA.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Song YX, Sun JX, Zhao JH, Yang YC, Shi JX, Wu ZH et al. Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion[J]. Nat Commun. 2017, 8(1):289.

Sequence

>gi|338651|ref|NR_021489.2| Homo sapiens KRTAP5-1/KRTAP5-2 antisense RNA 1 (KRTAP5-AS1), long non-coding RNA

000001 AGACCCAGGC GCGGCGTTTT ACCTGCAGCG GCTGTGCTCG CCCCGCCGCG ACCCCCGCAG GACGGAGCCG GATCCCCCTG 000080
000081 CACTCGGGCG GACCTGGGAC CCTCAGAGGC GAGCCGGCTG CCTCGGGTCA CACATCCGCG AACTCCGGGG GCGGGCTCCC 000160
000161 CAGGACGCCG CCGACCCCCC ACGACCCCCA GCCCTCCCGC TTCCGTGGAA AGCCGCCCCG ACGACCCCTG TGCGGGCTGT 000240
000241 TGAGGGGCCG CACCCCGCCG ACCGCTGTGG GAACACCTCC GCGCGTGCGG CGGGGACGCG GCGAGTCCGG GGCAGGAAGA 000320
000321 ACGCACGGAT GGAGACAACA GGAAGGAAAG AGACCTTCCT GGTCACACTT GGGCCACAGG AGAACAGGCA GCGGCCCAGG 000400
000401 AGGATCCAGG GTCCTGATGG TGGTTGAGAA GCTGGTTCTT AGTGATCACT CAGAAACGTC GGCCTGGCCT TGTGGGGTCA 000480
000481 GACCTTGCAT CTCAGTCAGC CCAGGGAGAA GAAGAAGATG GTCCACACCC AAGTGCAGGG AACATCGTGG CAGTCGGCTG 000560
000561 GGTGCCTGCG TCCAGGCGAG GACACCTCCC GCATCAGGGA AACACACGTT TCTGGAGTGA GGAGGCTGAA GGCAGGGCCC 000640
000641 AGAGGAGAGC TGAGCCATGG AAGGAGGTGT GTGCATGGAT GGTGAGCTAG AGCAGGTGCA GGTGCCTCAG GGAGGATGTG 000720
000721 TGGGACGAAC TGACTCAGGG AACCATAAGA AATGCTTTCA CCAAACAGGA GAAACCTGAA GGTCTGGGTC CAGAGCCTCA 000800
000801 GATCTTACAC TGGCAGCACA CAGGGACACA ACAGTTGGAC TGGCAGCAAC AGGGCTTGCA GCAGCTGGAC TGGCAGCACA 000880
000881 CGGGGACACA GCAGCTGGAC TGGCAGCAGC AGGGCTTGCA GCAGCTGGAC TGGCAGCAGG ATGATCCACA GCCTGAGGAG 000960
000961 CAGCAACAGG GCTTACAACA GCTGGACTGG GAGCAGCCAC AAGAACCACA GCCCCCCTTG GAACCCCCAC AGGAGCCACA 001040
001041 GCCCCCCTTG GAGCCCCCAC AGGAGCCACA GCCCCCCTTG GAGCCCCCAC AGGAGCCACA GCTGGTGCAG GAACAGGCTG 001120
001121 GCACCCAGGA GCACACGGGC TTGCAGCAGC AGACAGGCAC ATAACATCTG GAGCCACATC CCCCACAGCT GGAGCTGCAG 001200
001201 CCCCCACAGC CAGAGCCACA GCCCCCACGG CCGGAGCCAC AGCCCCCACA GCCAGAGCCA CAACCCCCAC AGCTGGAGCC 001280
001281 ACAGCCCCCA CAGCCGGAGC CACAGCCTCT GGAGCAGCCA CAGCAGCCCA TGGTTCTGGT GGATTGAGGG TGGAGCAGGT 001360
001361 AGAGGAGCAG GTGAGAGGGA GGTGCAGGTG TGGAGCTCCC TGAGCCTGGG CTCTTTATAT ACCTGTCCAG ATGTCAGGCA 001440
001441 TGACACAGGG TCCCTTTCTT GTGACTGTTT ACACTATTTT TCCAGAGCTC TATTTTTTTC CTCTTTGCTA GTGACTTCCT 001520
001521 TCTGGCTCAG TTGAGCATCT ACTTTCTTTG TTTTCTAAAT TTGTCTTTTT CCCCATTTGT TTTGGCCCCT ACAATTAAAA 001600
001601 CCTCAGCTCC AGGCTGTCTG GTTCTTCCTG CAAAGCTCCA GGGTGCTGGT CACCTGCTCT CTGCTGACCA CATGTGACCA 001680
001681 ATGGGCAACA GCCTCTGCCC ACGTGCTCTC ATCTTTCCTG TGTTGACTCC CTCAATAATA TTAATTTTAC ATTTTTAGAT 001760
001761 TTCAAAATTA TCCACGATCT TTATACTCAT GCCAGTCTCA GCTTTCCGGG TGTGTTAGAC CATTCTTTGC ATTGCTCTAA 001840
001841 AGAAATACTT GAGGCTGGGT AATTTATAAA GGAAAGAGGT TAGAATGGCT CATGGTTCTG CAGGCTGCAC AAGCATGGCA 001920
001921 CCCACCTCTG CTCAGCTTCT GGGGAGGCCC TCAGGGAGTT TTCCTCACGG TGGAAGGCGA AGCAGGAACA GGCACACCAC 002000
002001 ATGGTGAGAG TGGGAGCAAG GGGTGAGGAG GAGCCACACA CTTGTGAACA ACCAGATCTG AGTGAACACA CTCATCGCCA 002080
002081 AGGGGGTGGC ACTAAGTCAC TCATGAGGGA TCCACCCCCA TGACCCAGAC ACCTCCCTGC AGGCCCCTCC TTCAACACTG 002160
002161 GCCAACAACT ATATGAAAAA ATGCTCCACA TCACTAACTA TTCGGGGAAT GTAAATCGAA ACCACCACGA GATACCATCT 002240
002241 CATATCAGTC AGAATGGCTT TTGAT
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