HSALNG0007045
FALEC, FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21.
Contents
Annotated Information
Approved Symbol
FALEC
Approved Name
FALEC:focally amplified long non-coding RNA in epithelial cancer FAL1; ncRNA-a1; LINC00568
Characteristics
FALEC is a long noncoding RNA is located in a focal amplicon on chromosome 1q21.2. [1]
Function
FALEC is associated with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A [1]. The up-regulation of FALEC is connected with the poor prognosis of patients with melanoma [2]. FALEC could accelerate the proliferation of melanoma cells through influencing the cell cycle and apoptosis [1] Knockdown of FALEC blocks the metastasis, invasion and EMT process [2]. LncRNA FALEC is negatively correlated with p21 in melanoma tumorigenesis [2]. FALEC epigenetically silences p21 via binding to EZH2 [2]
Regulation
Please input regulation information here.
Diseases
Expression
FALEC is highly expressed in melanoma tissues and cell lines [2] After stratifying the 128 late-stage ovarian cancer patients with FALEC RNA expression (cut-off, median expression) or gene amplification status, we found that both higher expression of FALEC RNA and genomic gain of FALEC gene were significantly associated with decreased survival in patients (p<0.0001 and p=0.03, respectively. [1]
Labs working on this lncRNA
- Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China
- Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
- Center for Research on Reproduction & Women’s Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
- Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Hu X, Feng Y, Zhang D, et al. A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell. 2014;26(3):344-357.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Ni NN, Song H, Wang XP, Xu XL, Jiang YQ & Sun JF. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21[J]. Biomed Pharmacother. 2017, 96(1371-1379.
- ↑ Li BG, Mao R, Liu CF, Zhang WH, Tang Y & Guo Z. LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells[J]. Life Sci. 2018, 197(122-129.
- ↑ Jeong S, Lee J, Kim D, Seol MY, Lee WK, Jeong JJ et al. Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer[J]. Medicine. 2016, 95(4).
Sequence
>gi|100874054|ref|NR_051960.1| Homo sapiens focally amplified long non-coding RNA in epithelial cancer (FALEC), long non-coding RNA
000081 CGGTCCCACG TGTACCCTCC TGGCCTGGGT CGCCCCAGCC CACGGGGAGC GGGCGGAGTC CTGGCCCACG AAGCCTTGTC 000160
000161 ACCTGGCGGG CGAATCCGCA AGCGGAGACT TGTCTTTAAA GGGCTTTGGG CCGGGCGCGG TGGCTCATGC CTGGAATCCC 000240
000241 AGCACTTTGG GAGGCCGAGG CGGTGGATCA CGAGGTCAGG AGTTCAAGAC CAGCCTGGCC AAGAAGCTCA TACTGACTAA 000320
000321 GGCAGCAGAA CATACAGGAG GAAGAGGAGC AGGTTTCACA GAGGGAAGAC ATGAGTTCAA TTTTGGACTT CTCAGTAGTC 000400
000401 GGTGTCCTCA GTGGTAGCAA CTTCAAACGG AAGGTGTCAA AAGTCAAATT CTGGAGAGTT GAGTATGAAT GGGAGATGAA 000480
000481 GAAAAGGAGG CAGCACTTGT AGCCTGCTCT TAATGTATTT CTGCACTCTA CACTAGCAGC CTATTACACA GGACACTTGG 000560
000561 ATGTCT
