HOXC-AS1

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Annotated Information

Approved Symbol

HOXC-AS1 (HOXC cluster antisense RNA 1)

Chromosome

12q13.13

RefSeq(supplied by NCBI)

NR_047504

Expression of lncRNA HOXC-AS1 and HOXC6 in normal tissues and atherosclerotic plaques.[1]

Characteristics

lncRNA HOXC-AS1 is located on chromosome 12 and its transcription position is nearby.[1]

Expression

Compared to normal renal arterial intima, HOXC-AS1 is downregulated in carotid atherosclerosis.[1] Ox-LDL can suppress the expression of lncRNA HOXC-AS1 and HOXC6 in THP-1 macrophages.[1]

Experiment Forward primer Reverse primer
qRT-PCR 5′-CTGCGACACTTCCCCACC-3′ 5′-CTACTT GCCCACGACCGA-3′[1]

Function

Overexpression of HOXC-AS1 promotes expression of HOXC6 at mRNA and protein levels.

Labs working on this lncRNA

  • Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China .
  • Department of Anesthesiology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
  • Department of Vascular Surgery, Nanfang Hospital, Southern Medical University , Guangzhou, China .
  • Department of Cardiology, Nanfang Hospital, Southern Medical University , Guangzhou, China .

References

  1. 1.0 1.1 1.2 1.3 1.4 Huang, C., et al., Long Noncoding RNA HOXC-AS1 Suppresses Ox-LDL-Induced Cholesterol Accumulation Through Promoting HOXC6 Expression in THP-1 Macrophages. DNA Cell Biol, 2016. 35(11): p. 722-729.