HIF1A-AS1

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Annotated Information

Approved Symbol

HIF1A-AS1

Approved Name

HIF1A antisense RNA 1

Previous Symbols & Names

HIF1A antisense RNA 1 (non-protein coding)

Synonyms

5'aHIF-1A

Chromosome

14q23.2

Silencing efficiency of sh HIF1A-AS1 was verified by qRT-PCR [1].

RefSeq ID

NR_047116

OMIM ID

614528

Ensembl ID

ENSG00000258777

pubmed IDs

21897117, 24875884

Characteristics

There are two antisense lncRNAs at the 5'(5'aHIF-1A or HIF1A-AS1) and 3'(3'aHIF-1A) ends of the human HIF-1A gene, and they are recovered mainly in the nuclear fractions. [2]

Function

HIF1A-AS1 is activated in response to partially different kinds of stress, such as low oxygen tension and Top1-mediated transcriptional stress and DNA damage.[2] Suppression of the lncRNA HIF1A-AS1 by siRNA in VSMCs will reduce cell apoptosis and promote cell proliferation.[1]


Disease

kidney cancer

Regulation

HIF1A-AS1 expression is up-regulated by 3.26-fold compared with control by BRG1 overexpression, and down-regulated to 0.37-fold by BRG1 silencing.[1]

Sequence

>gi|537361086|ref|NR_047116.1| Homo sapiens HIF1A antisense RNA 1 (HIF1A-AS1), long non-coding RNA

000001 CGCCGCCGGC GCCCTCCATG GTGAATCGGT CCCCGCGATG TCTTCACGGC GGGCGGCCCC CAGGCTCGCT CCGGCCTAAG 000080
000081 CGCTGGCTCC CTCCACACGC GGAGAAGAGA AGGAAAGACT ACAGTTCAAC TGTCAATTGG TTGATCACCC GGATTTTATC 000160
000161 TACACCTTAG CCTATGGTTG TTCATCTCGT CTCTGCCTAT GGCCCATTGA CTCCCGGATC CCAGCTCCAT TCTTCGGTAC 000240
000241 TTTACGCACC CTGCTTCCAG TACCCCAACC AGAAGAATAT ATATAGCAGT TAACTGTCAG CTGGCGAAAA GGAGGAAAAT 000320
000321 TCAGGAAGAT AAAATAGCTG AATGAATTAT CCCCGCTCCA GAACGCAGAG GAAAAATGAA ATGGCCAGAC CCAGATGTTA 000400
000401 AAAATGTGTT CCTTGCTCTT TCCTGCCCTA GCAAGGGCTG TTCCATGTTT AGGGGATGAA TGCCGCTGAG AGTATTAGCA 000480
000481 AAAATACATG TGTCATTGAG TCTGAGGAAG ATAACTGAGA CATACAGGTA TTTCTCATAA TGCATGTGGG CATCCATAGA 000560
000561 CATATTCTTA AATGGCTTAA GGACTTGGAA ACTACCTCTA GGAAACCTGA AACTTGAATG TTGGTCCACT AGGGAGAAGA 000640
000641 AATGTTCCAT TA

Labs working on this lncRNA

  • Department of Biochemistry “G. Moruzzi”; University of Bologna; Bologna, Italy [2].
  • Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China .[1]

References

  1. 1.0 1.1 1.2 1.3 Shuwei Wang, Xiwu Zhang,Yang Yuan, Mengwei Tan, Le Zhang, Xiang Xue, Yan Yan,Lin Han and Zhiyun Xu."BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro." European Journal of Cardio-Thoracic Surgery 47 (2015) 439–446.
  2. 2.0 2.1 2.2 Bertozzi, D., R. Iurlaro, O. Sordet, J. Marinello, N. Zaffaroni, and G. Capranico. "Characterization of Novel Antisense Hif-1alpha Transcripts in Human Cancers." Cell Cycle 10, no. 18 (2011): 3189-97.