Difference between revisions of "HCG14"

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Latest revision as of 09:29, 26 December 2018

HCG14, HLA complex group 14 long non-protein coding gene that carries a novel celiac disease risk variant.

Annotated Information

Name

HCG14: HLA complex group 14 (HGNC:18323)

Alias

dJ111M5.4 (HGNC:18323)

Characteristics

HCG14 is a long non-protein coding RNA gene at chromosome location 6p22.1. A risk variant in HCG14 contributes to celiac disease pathogenesis.[1]

Function

This lncRNA seems to regulate the expression of NOD1 in an allele-specific manner.[1]

Regulation

Please input information here.

Expression

Expression of HCG14 was slightly downregulated in epithelial cells isolated from duodenal biopsies of celiac patients, and eQTL analysis revealed that polymorphisms in HCG14 region were associated with decreased NOD1 expression in duodenal intestinal cells.[1]

Disease

Celiac disease [1]

Labs working on this lncRNA

  • Endocrinology and Diabetes Research Group, BioCruces Health Research Institute, UPV-EHU, CIBERDEM, Barakaldo.
  • Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV-EHU), BioCruces Health Research Institute, Leioa.
  • Department of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastian.
  • Department of Pediatrics, University of the Basque Country (UPV-EHU), Cruces University Hospital, Barakaldo, Spain.

References

  1. 1.0 1.1 1.2 1.3 Santin I, Jauregi-Miguel A, Velayos T, Castellanos-Rubio A, Garcia-Etxebarria K, Romero-Garmendia I et al. Celiac Diasease–associated lncRNA Named HCG14 Regulates NOD1 Expression in Intestinal Cells[J]. Journal of pediatric gastroenterology and nutrition. 2018, 67(2):225-231.

Sequence

>gi|414760|ref|NR_104117.1| Homo sapiens HLA complex group 14 (HCG14), long non-coding RNA

000001 GGCCTTATAA CTGTTATCGC CATCTCGAAA AACGTGTGCG GGTTTTTTTT TTTTTTTTTT TTGCTCCCAG CCTGCCCAGA 000080
000081 TTTCAGGAAG GAAAGAAGAT CTTTTGCTTC TTCGGTCGCT GGGTCGGCTC TCCAGTGTCT GATGTTTACT GAAATCTTGA 000160
000161 TCGTGGTTAG CCTCCCCCAG GACTTCATTG TTTGGAAGAT GCCTTCGCCA AGCAATCTGA GCTCCAGGCC GGGAAGCCCC 000240
000241 AAGGTCACAA ATTTTAATGG AGCCCTGAAA CTAAACAGAA ATCATCCCTC CCACTAGAAC AAGAGCCCCT AGAGGCCAGC 000320
000321 GACACCGCTA AAATAACATG TGTAGACCAA TGCCGTCCAG GTAACAGTGC CTGGCAAACA CGGTAGAGGT TCAATAAATA 000400
000401 CATTTTAACT C