Gilles de la Tourette syndrome chromosome region, candidate 1 (non-protein coding)
GTSCR-1 encodes a putative product of 138 aa in three exons; the protein shows no significant homology to other proteins, ESTs, or protein motifs.
DHPLC evaluation of coding regions and intron–exon splice junctions for the transcripts GTSCR-1 reveals no missense or nonsense mutations in a group of 96 patients with GTS, OCD, and CT (Tables 1 and 2, which are published as supporting information on the PNAS web site).
Gilles de la Tourette syndrome (GTS)
>gi|512125225|ref|NM_001278515.1| Homo sapiens Gilles de la Tourette syndrome chromosome region, candidate 1 (non-protein coding) (GTSCR1), mRNA
Labs working on this lncRNA
- Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA. Matthew.State@Yale.edu
- State MW, Greally JM, Cuker A, Bowers PN, Henegariu O, Morgan TM, Gunel M, DiLuna M, King RA, Nelson C, Donovan A, Anderson GM, Leckman JF, Hawkins T, Pauls DL, Lifton RP, Ward DC. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4684-9.