Difference between revisions of "GAU1"

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Latest revision as of 06:08, 22 December 2018

GAU1, GALNT8 antisense upstream 1 is a novel non-coding transcript in tumors.

Annotated Information

Name

GAU1: GALNT8 antisense upstream 1 (HGNC:53880)

Alias

GALNT8-DT: GALNT8 divergent transcript (HGNC:53880)

Characteristics

The previously identified GAU1 lncRNA (LOC101929549)located at chromorsome 12p13.32 is 1,294 bp in length according to the University of California, Santa Cruz (UCSC) and the NCBI databases. . In a study, however, a novel 1339-bp isoform of LOC101929549 was reported named lncRNA GALNT8-antisense-upstream1 (GAU1), a novel transcript that differs from the previously determined genomic boundaries by 57 bp at the 5′ terminus and by 4 bp and a poly-A tail at the 3′ terminus. This isoform of the LOC101929549 lncRNA identified in retinoblastoma and neuroblastoma is a novel non-coding transcript; and therefore named GALNT8-antisense upstream 1 (GALNT8-AU1 or GAU1; GenBank: MF576259). [1]

Function

GAU1 is a novel oncoRNA that promotes tumorigenesis in neuroblastoma and retinoblastoma. lncRNA GAU1 cis-regulates the expression of its downstream target gene, GALNT8. GAU1 recruits transcription factor TCEA1 to the GALNT8 promoter and activates the expression of GLANT8.[1]

Regulation

Please input information here.

Expression

When GAU1 or GALNT8 was overexpressed in normal cells (RPE1 and ARPE19), cell colonies were significantly increased in GAU1-overexpressed and GALNT8-overexpressed normal cells. Moreover, the cell proliferation was also promoted, either in GAU1-overexpressed or in GALNT8-overexpressed normal cells, indicating that GAU1 lncRNA and GALNT8 play an oncogenetic regulatory role and that the GAU1/GALNT8 cluster may serve as a potential cancer-driving chromosomal region. [1]

Diseases

  • Neuroblastoma [1]
  • Retinoblastoma [1]

Labs working on this lncRNA

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, P.R. China

References

  1. 1.0 1.1 1.2 1.3 1.4 Chai P, Jia R, Jia R, Pan H, Wang S, Ni H et al. Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis[J]. Nucleic acids research. 2018, 46(12):6041-6056.

Sequence

>gi|101929549|ref|NR_110112.1| Homo sapiens GALNT8 antisense upstream 1 (GAU1), long non-coding RNA

000001 TGCCTTTTAA ACGCTTGTTC TGTCTCTTTC TAACTCCTTT GTCTCCGCCG GACTCGGGGT ATCCGCTGGG TGGTGTGGGG 000080
000081 CTGGTTTCCC CAACAGCTTT CTCTCCACCC AGCTTCATAG ATGACACCCT GCCTGCTAGG CCAGATGTTC TCCGGCCAAG 000160
000161 AACACTATTA TAGCTGCCTG GCTTCTCCCT GAGCAGCGTC AGGTGTGAGG AGTGCGCATG GCAGCTGCCC AGTGACAGAT 000240
000241 GGAATCTCCC TCTCTCACCC AGGCTGGAGT GCAATGGCAC AATCAGCTCA CTGCAACCTC CACCTCCCGG GTTCAAGTGA 000320
000321 TTCTTCTGCC TCAGCCTCCC GAGTAGCTGG GACTACAGCC TTCATTTCAG TCAACAACCA CATAACAGAT CATCAAAATA 000400
000401 CATAAAGCAA AAACTGACAG AACTAAAGTT AAATATACAT ATCTACAATT ATGTAGAGAA TAACAAACAA AAAAATAGAA 000480
000481 CAAAAATGTT CCACGCCTTG GTCAATGGTA CCACCAGCCA GCGAGGTTCC CAAGCCAAGA ACTTCGGAAG CATCCGTGAT 000560
000561 TCTTCATCTT CCACATCCAC TTTATCACCG GAAGCACGCA TTCAACTTTC TAAACATCCC TCAGACTGAC CCACATCTTT 000640
000641 CTATCCACTT TTCACATCTT GCTTGAATGA CTTCCCCAGG CCCAGCCAGT CTCCCGCCTC CAGCTCCGCC CCCTTCTGAC 000720
000721 TCCCTTTATG TGGTACAATC AGAGAGCCCT TCCCAAAGCA CAAATCTGCT TTCACTGCTT TGCTTCAAGC CCTTTCGTGG 000800
000801 CTCCTATTTC CAGCTGGATG AGGTCCAAGC CTCTTAACGT GCTGTACGTG TACATGCCTG ACCCCCGCTA CTTGACCAGC 000880
000881 CAAGTTTCTT CATAGCGCTG TGTCTTTGTT CCTCCTGCCT AGAATGTCCT TCCCCTTTTC TCTCGCTTCA TGGTGTGCCA 000960
000961 AACTCCTATC CTGTGAGATC CAGCTTACAC GTCAGCTTCC CCGTGATGCT TTTCCTAACT CCCTATTCAG CCAGTGAAGT 001040
001041 GCTCCCTGCG TTCCCATGTG GCTTGTATCT CTGTAAAAGC TCCACAGAGC TGTTTTAATT TATCCGTTAA TGTACATGTC 001120
001121 TTCCCCACTA GACTTTTGCT CCTTAAAGTA TCTCCTTCAT CTCTGCTTTG CATAACCTAA CAGAGTTCAA CACATAGGAG 001200
001201 TGTCTTAATA AATGCTGAAT AAAATAATTA ATAAACAAAT GAAACAATA