Difference between revisions of "GAU1"
(Created page with "''GAU1'', GALNT8 antisense upstream 1 is a novel non-coding transcript in tumors. ==Annotated Information== ===Name=== ''GAU1'': GALNT8 antisense upstream 1 [https://www.gene...")
Latest revision as of 06:08, 22 December 2018
GAU1, GALNT8 antisense upstream 1 is a novel non-coding transcript in tumors.
GAU1: GALNT8 antisense upstream 1 (HGNC:53880)
GALNT8-DT: GALNT8 divergent transcript (HGNC:53880)
The previously identified GAU1 lncRNA (LOC101929549)located at chromorsome 12p13.32 is 1,294 bp in length according to the University of California, Santa Cruz (UCSC) and the NCBI databases. . In a study, however, a novel 1339-bp isoform of LOC101929549 was reported named lncRNA GALNT8-antisense-upstream1 (GAU1), a novel transcript that differs from the previously determined genomic boundaries by 57 bp at the 5′ terminus and by 4 bp and a poly-A tail at the 3′ terminus. This isoform of the LOC101929549 lncRNA identified in retinoblastoma and neuroblastoma is a novel non-coding transcript; and therefore named GALNT8-antisense upstream 1 (GALNT8-AU1 or GAU1; GenBank: MF576259). 
GAU1 is a novel oncoRNA that promotes tumorigenesis in neuroblastoma and retinoblastoma. lncRNA GAU1 cis-regulates the expression of its downstream target gene, GALNT8. GAU1 recruits transcription factor TCEA1 to the GALNT8 promoter and activates the expression of GLANT8.
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When GAU1 or GALNT8 was overexpressed in normal cells (RPE1 and ARPE19), cell colonies were significantly increased in GAU1-overexpressed and GALNT8-overexpressed normal cells. Moreover, the cell proliferation was also promoted, either in GAU1-overexpressed or in GALNT8-overexpressed normal cells, indicating that GAU1 lncRNA and GALNT8 play an oncogenetic regulatory role and that the GAU1/GALNT8 cluster may serve as a potential cancer-driving chromosomal region. 
Labs working on this lncRNA
Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, P.R. China
- Chai P, Jia R, Jia R, Pan H, Wang S, Ni H et al. Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis[J]. Nucleic acids research. 2018, 46(12):6041-6056.
>gi|101929549|ref|NR_110112.1| Homo sapiens GALNT8 antisense upstream 1 (GAU1), long non-coding RNA