Difference between revisions of "ENST00000517411.1"

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===Expression===
 
===Expression===
 
MINCR strongly correlates with MYC expression in not only BL but more in general, GC-derived MYC-positive lymohomas and other cancer types, like pancreastic ductal adenocarcinomas, that are known to rely on MYC expression<ref name="ref1" />.
 
MINCR strongly correlates with MYC expression in not only BL but more in general, GC-derived MYC-positive lymohomas and other cancer types, like pancreastic ductal adenocarcinomas, that are known to rely on MYC expression<ref name="ref1" />.
 
===Allelic Information and Variation===
 
Please input allelic information and variation information here.
 
  
 
===Evolution===
 
===Evolution===
Please input evolution information here.
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MINCR is conserved throughout primates, with the exception of Galago, but not in other vertebrates <ref name="ref1" />.
 
 
You can also add sub-section(s) at will.
 
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==

Revision as of 08:35, 22 April 2016

MINCR, short for MYC-induced long noncoding RNA, is a novel player in MYC transcriptional network,with the potential to open new therapeutic windows in the fight against maglignant lymphoma and, possibly, all cancers that rely on MYC expression.

Annotated Information

Transcriptomic Nomeclature

MINCR: MYC-induced long noncoding RNA [1] LINC01604, "long intergenic non-protein coding RNA 1604"[1]

Characteristics

The MINCR gene, which is located on chromosome 8q24.3 and intergenic to the two coding genes GLI4 and ZNF696, has a long transform composed of three exons. It is ubiquitously expressed, with the highest expression values in brain, prostate, and testis [1].

Function

MINCR could interplay with transcriptor MYC to co-regulate the expression level of a group of genes involved in cell cycle initiation and progression [1].

Regulation

MINCR is found to be induced by MYC in not only restricted to B cell line but in MYC-regulated retinal pigment epithelial cell line hT-RPE-MycER [1].

Expression

MINCR strongly correlates with MYC expression in not only BL but more in general, GC-derived MYC-positive lymohomas and other cancer types, like pancreastic ductal adenocarcinomas, that are known to rely on MYC expression[1].

Evolution

MINCR is conserved throughout primates, with the exception of Galago, but not in other vertebrates [1].

Labs working on this lncRNA

  • Fred Hutchinson Cancer Research Center [1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Doose G, Haake A, Bernhart SH, Lopez C, Duggimpudi S, Wojciech F, et al. MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells[J]. Proceedings of the National Academy of Sciences of the United States of America. 2015,112(38):E5261-70.

Basic Information

Transcript ID

ENST00000517411.1

Source

Gencode19

Same with

lnc-TOP1MT-2:5

Classification

intergenic

Length

645 nt

Genomic location

chr8-:144362336..144363830

Exon number

3

Exons

144362336..144362685,144363052..144363167,144363652..144363830

Genome context

Sequence
000001 TCGCGTGTCT TCCGAACTCT GCTGCTTCGC CCCGGCAAGA GCACTTCCTT CCGCGGCTGC TAAAACTGGT GCGCGGGTTC 000080
000081 CCAACTTCGC AGAAGAGCTT CATCGGCCCC CCGCTAGAGA CCTCAGACCG CAGCCATCGA CGCCTCGCCT CGGGGATCTG 000160
000161 TCCCCACCCT CGGGGCCAGC TCACCATGAG TCAGGCCCTG TGCTAGGTGC TGGGATGAAG CAGTGACTGA CACAGGCCTG 000240
000241 GACCTGTCCT TGGGAAGAGT GCGTCTGTGA CACAGATACT GTGCCATGTG GCAAAACTTG AATGGAGACA TCAGCTCTTT 000320
000321 GTGGGTCTCA AGTCTACTGG CTTTCAATCA GCTCTTCTGC TTGACAGCTG CAGGTCTTGG GACTGCCCAG CCCCCATAAC 000400
000401 CCTGTGAGTG CATTCCTGAT AATAACCCTC TTTCTCTTGT CCTCCCCCAC CCCACATCAT TGGTTCTGTT TCTCTGGAGA 000480
000481 ACCATAATAC ATCATTTACT AATCAGGAAA TAGATTCAGA GACATTAATA ACTCATCCAA CCTCACAGTT AACTGTAGAG 000560
000561 TTGGGCTTGA AATTCCAAGG TCGATTTTCT TAGCCAATAC ACCATGCTAC ATATATGTAT GTAAAAATAA AAACGCTTGT 000640
000641 GAACT
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