Difference between revisions of "EGFLAM-AS1"

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(Created page with "==Annotation== ===Name=== EGFLAM-AS1 ===Alias=== lncRNA-LOWEG ===Disease=== Disease: gastric cancer [http://www.ncbi.nlm.nih.gov/pubmed/26537802 (PMID:26537802)] Dysfunctio...")
 
(Labs working on this lncRNA)
 
(One intermediate revision by the same user not shown)
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==Annotation==
 
==Annotation==
 
===Name===
 
===Name===
EGFLAM-AS1
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Approved symbol: EGFLAM-AS1
  
===Alias===
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Alias: lncRNA-LOWEG, CTD-2108O9.1
lncRNA-LOWEG
 
  
===Disease===
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HGNC ID:HGNC:41169
Disease: gastric cancer [http://www.ncbi.nlm.nih.gov/pubmed/26537802 (PMID:26537802)]
 
  
Dysfunction type: interaction
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Ensembl ID: ENSG00000249491
  
Description: Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level.
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LncBook transcript ID: HSALNT0086786
  
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===Characteristics===
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-
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===Function===
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[[File:EGFLAM-AS1-fun.png|right|thumb|400px|Downregulation of long non-coding RNA (lncRNA)-CTD-2108O9.1 in breast cancer and its inhibitory effects on
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metastasis through its associated metastatic inhibitor leukemia inhibitory factor receptor (LIFR), epithelial-mesenchymal transition (EMT)-related genes and MMP family<ref name="ref2" />.]]
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*lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor(LIFR), which is designated as a metastasis suppressor in BC<ref name="ref2" />.
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===Regulation===
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-
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===Diseases===
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Gastric cancer<ref name="ref1" />
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Breast cancer<ref name="ref2" />
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===Expression===
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Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level<ref name="ref1" />.
  
===Function===
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RNA-CTD-2108O9.1 is downregulated in Breast cancer (BC) tissues and cells and acts as a metastatic inhibitor of BC<ref name="ref2" />.
Function Mechanism: NA [http://www.ncbi.nlm.nih.gov/pubmed/26537802 (PMID:26537802)]
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===Evolution===
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-
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==Labs working on this lncRNA==
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*Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
  
Biological Process: pathogenic process
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*Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China
  
Description: suppressor
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==References==
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<references>
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<ref name="ref1">
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Zhao J, Sun J, Song Y, et al. A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion[J]. Journal of cancer research and clinical oncology, 2016, 142(3): 601-609.
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</ref>(1)
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<ref name="ref2">
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Wang M, Wang M, Wang Z, et al. Long non‐coding RNA‐CTD‐2108O9. 1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor[J]. Cancer science, 2018, 109(6): 1764-1774.
 +
</ref>(2)
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</references>

Latest revision as of 07:08, 14 August 2019

Annotation

Name

Approved symbol: EGFLAM-AS1

Alias: lncRNA-LOWEG, CTD-2108O9.1

HGNC ID:HGNC:41169

Ensembl ID: ENSG00000249491

LncBook transcript ID: HSALNT0086786

Characteristics

-

Function

Downregulation of long non-coding RNA (lncRNA)-CTD-2108O9.1 in breast cancer and its inhibitory effects on metastasis through its associated metastatic inhibitor leukemia inhibitory factor receptor (LIFR), epithelial-mesenchymal transition (EMT)-related genes and MMP family[1].
  • lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor(LIFR), which is designated as a metastasis suppressor in BC[1].

Regulation

-

Diseases

Gastric cancer[2]

Breast cancer[1]

Expression

Significantly reduced expression of lncRNA-LOWEG was found in gastric cancer tissues and cell lines (SGC-7901, AGS, BGC-823 and HG-27) compared with patient-matched nontumorous adjacent tissues (P < 0.01) or the normal gastric cell line GES-1 (P < 0.05). Lastly, western blot and real-time PCR analysis suggested that lncRNA-LOWEG is positively correlated with the expression of leukemia inhibitory factor receptor (LIFR) gene at the translational level[2].

RNA-CTD-2108O9.1 is downregulated in Breast cancer (BC) tissues and cells and acts as a metastatic inhibitor of BC[1].

Evolution

-

Labs working on this lncRNA

  • Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
  • Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China

References

  1. 1.0 1.1 1.2 1.3 Wang M, Wang M, Wang Z, et al. Long non‐coding RNA‐CTD‐2108O9. 1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor[J]. Cancer science, 2018, 109(6): 1764-1774.
  2. 2.0 2.1 Zhao J, Sun J, Song Y, et al. A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion[J]. Journal of cancer research and clinical oncology, 2016, 142(3): 601-609.