Difference between revisions of "DEC1"

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(Created page with "''DEC1'', an antinsense transcript required for tumorogenicity of ovarian and colorectal cancer cells ==Annotated Information== ===Name=== ''DEC1': deleted in esophageal canc...")
 
 
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''DEC1'', an antinsense transcript required for tumorogenicity of ovarian and colorectal cancer cells
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''DEC1'', a candidate tumor suppressor in 9q32
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==Annotated Information==
 
==Annotated Information==
 
===Name===
 
===Name===
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''DEC1': deleted in esophageal cancer 1
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Approved symbol: DEC1
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 +
Approved name: deleted in esophageal cancer 1
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HGNC ID: HGNC: 23658
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Aliases: CTS9, Candidate Tumor Suppressor CTS9
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RefSeq ID: NR_163556
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===Characteristics===
 
===Characteristics===
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''BTB3-AS1'' is a member of the TOB/BTG family of antiproliferative genes that regulates cell cycle progression in a variety of cell types <ref name="ref3" />
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[[File:ASBEL-1.JPG|right|thumb|400px|'''ASBEL is transcribed from the DNA strand opposite to ANA/BTG3'''<ref name="ref1" />.]]
 
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''BTB3-AS1'' is an antisense transcript of ANA/BTG3. it is a highly conserved gene encoded by the DNA strand opposite the ANA/BTG3 gene.
 
  
 
===Function===
 
===Function===
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In ovarian carcinoma, ''BTB3-AS1'' promotes tumorigenesis through suppressing translation of the sense gene (ANA/BTG3) <ref name="ref1" />. ''BTB3-AS1'' forms duplexes with ANA/BTG3 mRNA in the nucleus and suppresses its cytoplasmic transportation, leading to negative regulation of ANA/BTG3 at protein level without changing of its mRNA level <ref name="ref1" />.  
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''DEC1'' cDNA can suppress growth of some cancer cells in vitro, it is a candidate tumor suppressor in 9q32 <ref name="ref1" />.
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''BTB3-AS1'' also plays a key role in Wnt/β-catenin-mediated tumorigenesis <ref name="ref2" />. ''BTB3-AS1'' interacts with and recruits transcription factor 3 (TCF3) for activating transcription factor 3 (ATF3) locus and represses the expression of ATF3, resulting in proliferation and tumorigenicity of colon tumor cells <ref name="ref2" />. 
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===Regulation===
 
===Regulation===
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β-catenin is found to directly enhance the transcription of ''BTB3-AS1'' <ref name="ref2" />.
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===Disease===
 
===Disease===
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*Colorectal cancer <ref name="ref2" />
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*esophageal squamous cell carcinoma <ref name="ref1" /><ref name="ref2" />
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*Ovarian carcinoma <ref name="ref1" />
 
  
 
===Expression===
 
===Expression===
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''BTB3-AS1'' is highly expressed in stage I–III colon cancer than in normal tissues <ref name="ref2" />.
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The DEC1 gene is expressed in most normal human tissues, including the esophagus, but its expression is lower than normal, often absent, in more than half of the esophageal carcinomas examined <ref name="ref1" />.
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==Labs working on this lncRNA==
 
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*Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
 
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*Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
 
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*Division of Oncology, Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, 461 Shirokanedai, Tokyo, 108-8639, Japan.
 
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==References==
 
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<references>
 
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<ref name="ref1"> </ref>(1)
 
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<ref name="ref2"> </ref>(2)
 
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</references>
 
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===Sequence===
 
===Sequence===
 
>PREDICTED: Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1
 
>PREDICTED: Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1
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AGTATAGTTTTCAAATGTTACAGACCCCAAACACCAGTGTTTTATTGCCTACAGCAAGCATAGCTCACAG
 
AGTATAGTTTTCAAATGTTACAGACCCCAAACACCAGTGTTTTATTGCCTACAGCAAGCATAGCTCACAG
 
ATCATCAC</dnaseq>
 
ATCATCAC</dnaseq>
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==Labs working on this lncRNA==
 +
*Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
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*Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan.
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 +
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==References==
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<references>
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<ref name="ref1"> Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes Cancer. 2000 Feb;27(2):169-76.</ref>(1)
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<ref name="ref2">Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y. Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a  region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. Cancer Res. 1996 Apr 1;56(7):1629-34.</ref>(2)
 +
</references>

Latest revision as of 04:03, 12 August 2019

DEC1, a candidate tumor suppressor in 9q32

Annotated Information

Name

Approved symbol: DEC1

Approved name: deleted in esophageal cancer 1

HGNC ID: HGNC: 23658

Aliases: CTS9, Candidate Tumor Suppressor CTS9

RefSeq ID: NR_163556


Characteristics

Function

DEC1 cDNA can suppress growth of some cancer cells in vitro, it is a candidate tumor suppressor in 9q32 [1].


Regulation

Disease

  • esophageal squamous cell carcinoma [1][2]

Expression

The DEC1 gene is expressed in most normal human tissues, including the esophagus, but its expression is lower than normal, often absent, in more than half of the esophageal carcinomas examined [1].

Sequence

>PREDICTED: Homo sapiens deleted in esophageal cancer 1 (DEC1), transcript variant X1

000001 CTTCCAGTTC TGGAGGCTGG GAAGTGGAAG AGCATTGTGC CAGCACCTGG TGAGGGCCTT CTTGCCGTGT TACACATGAT 000080
000081 GGTTTTTACT GATGCCCTGC ACAGAGAGAG GTCTGTAAAG TGGCAAGCAG GAGTCTGCTA CAATGGAGGA AAGGATTTTG 000160
000161 CTGTATCTCT TGCCAGGCCC AAGGCTGCAG AGGGAATTGG TAATATACTT CATTTAATAA TAGTGTTTTA AGGGACATTA 000240
000241 TCATTTCATC CTATGTGGTA GATGTGATCA TCTTCATCTC ACAGATGAAA AGAGACAAAC CTGGGATTCA GAGGTACTTG 000320
000321 CCTATGAGTT TCTTACAGAT TTCCTCTTAC AATCCAGAAC TGCTGATTCC TGGGTCAGTG TCCTTTCCAA TATGGCATCT 000400
000401 TAGGCATGGC AATAAGTGAG ATCTAAAAGC TAGTTATTTG ATGCTTGGAC AAAGGCTTAG GGCATGGGCT TTGACCTAAT 000480
000481 GAATCAGTAG ATTCTAGTCT AATATTTTAA AGGATTTGAA ATGATTCCAG TTTATAAGCC CCTTTAACTG TCTTCTAAGA 000560
000561 TGTGGCTAAA CATTCCAACC TTCCTTAGCT CAAAAGTGGA CAAAACAAGA GATTACACAT GTTGATACTT TGGGAGTCAT 000640
000641 AGAAAATTCA CATATACATA GGCAGAGTGG TTCTGTAATT AACCAAATCT TTAGAGGTCC AAGGTTAACA GTATTGACCA 000720
000721 TTCATAATTA GCCATAAACT CAGACATTTT AAAAGCCTCA TGAAAATAGA AGTATAGTTT TCAAATGTTA CAGACCCCAA 000800
000801 ACACCAGTGT TTTATTGCCT ACAGCAAGCA TAGCTCACAG ATCATCAC

Labs working on this lncRNA

  • Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan.


References

  1. ↑ 1.0 1.1 1.2 Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes Cancer. 2000 Feb;27(2):169-76.
  2. ↑ Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y. Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. Cancer Res. 1996 Apr 1;56(7):1629-34.
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