Difference between revisions of "DARS-AS1"

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===Characteristics===
 
===Characteristics===
−
DARS-AS1 is anti-sense of DARS (aspartyl-tRNA synthetase). <ref name="ref1" />
+
DARS-AS1 is anti-sense to DARS (aspartyl-tRNA synthetase) <ref name="ref1" />.
  
 
===Cellular Localization===
 
===Cellular Localization===
−
According to the database of NCBI, the location of DARS-AS1 (NR_110199) is positioned at chr2: 136742746-136765112. <ref name="ref1" />
+
The location of DARS-AS1 (NR_110199) is positioned at chr2: 136742746-136765112 <ref name="ref1" />.
  
 
===Function===
 
===Function===
−
DARS-AS1 inhibited apoptotic cell death under hypoxia.<ref name="ref1" />
+
DARS-AS1, regulated by HIF-1, is found to inhibit apoptotic cell death in the renal tubular epithelial cells under hypoxia <ref name="ref1" />.
 +
 
 
===Regulation===  
 
===Regulation===  
−
HIF-1 binds to the Hypoxia-Responsive Elements (HREs) in the promoter region of DARS-AS1 and up-regulates its expression under hypoxia. <ref name="ref1" />
+
HIF-1 binds to the Hypoxia-Responsive Elements (HREs) in the promoter region of DARS-AS1 and up-regulates its expression under hypoxia <ref name="ref1" />.
 +
 
 
===Diseases===
 
===Diseases===
 
Renal disease<ref name="ref1" />
 
Renal disease<ref name="ref1" />
 +
 
===Expression===
 
===Expression===
−
The result of RNA-seq showed that the RPKM of DARS-AS1 is commonly up-regulated under hypoxia in both tubular cells.<ref name="ref1" />
+
DARS-AS1 is commonly up-regulated under hypoxia in tubular cells <ref name="ref1" />.
  
 
===Sequence===
 
===Sequence===

Revision as of 08:38, 15 August 2017

Annotated Information

Name

DARS-AS1:DARS antisense RNA 1[1]

Characteristics

DARS-AS1 is anti-sense to DARS (aspartyl-tRNA synthetase) [1].

Cellular Localization

The location of DARS-AS1 (NR_110199) is positioned at chr2: 136742746-136765112 [1].

Function

DARS-AS1, regulated by HIF-1, is found to inhibit apoptotic cell death in the renal tubular epithelial cells under hypoxia [1].

Regulation

HIF-1 binds to the Hypoxia-Responsive Elements (HREs) in the promoter region of DARS-AS1 and up-regulates its expression under hypoxia [1].

Diseases

Renal disease[1]

Expression

DARS-AS1 is commonly up-regulated under hypoxia in tubular cells [1].

Sequence

>NR_110199.1 Homo sapiens DARS antisense RNA 1 (DARS-AS1), transcript variant 1, long non-coding RNA

000001 CGCTTCTAGT AGGCCAAACT CCCAGGTGAC CCCCGCAAGA AACGCGGTCC GGAGAGGGTC TGGCCCCACT GCTGGGGCAA 000080
000081 GGGCTCTAGG CGCCCGGACC CCACGCCCGC AGCCTGCGGA GAACGTGCCG ACAAGGACCT GTAGGGCCCC ACTCCCCCTC 000160
000161 CTCCCTCCCT CGGCGCAGCC CGGCCCAGGG GTCTGTCCTC CCAGGCCCAG GAAAGGAGGA AACCCACTTC CGCCGCGTCC 000240
000241 ATGATCTCCC GCGGCTTCTC CTGACTCTTG CGGCTGGCGC TGGCGCTGGG CATCGGGACA CGGAACTGGG CAGTGGACAC 000320
000321 CACCCTCCCT CGCAGGCTTC CAAAGTAATT TGAAGGCCTT CCCTGACTTA AAGTGGATGC TGCTTTGGAA AGCACTGGAA 000400
000401 AAATGGATCC TGTCTTTCTT AGCCAAGGAC TGGTCTCTTT TCTCCAATGT GTCCCTAACA GAGTGGTGAG GCTGGCTCTT 000480
000481 CCCACCAGTA CAGGAAGATC ATTCCTTAAA AGAAATAGCC ATATGGCTTA TAAGGGACTA TATCTTAAGA CTATGTGTCT 000560
000561 TCTGCAGTTC TTTGCATAGA GTCAACGTTG AAGGACAAGC AACTTCAAAT TTCCAAGCAA CAAAATTATG TTCGGGTGGT 000640
000641 TTTCTGAAAG CGAGATCTTA AGAACCACCT GTATCAGAAT CCCATGAAGA GCTTGTTTAG TGTGCAAATT TACAGATTGT 000720
000721 CCCCCCTCAG AAATGCTCAT TTAGGAGTTC CTGTCCTTTG CGGGGACATG GATGAAGCTG GAAACCATCA TTCTCAGCAA 000800
000801 ACTAACACAG GAACAGAAAA CCAAACACTG CATGTTCTCA CTCAAAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA 000880
000881 G

Labs working on this lncRNA

  • Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017 Apr;5(8). pii: e13203.
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