DACOR1

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Annotated Information

Approved Symbol

DACOR1

Approved Name

DNMT1-associated colon cancer repressed lncRNA 1

Previous Symbols

Synonyms

TCONS_00023265

Chromosome

15q22.33

OMIM ID

_

Ensembl ID

_

pubmed IDs

26307088

Disease

  • colon cancer[1]

Function

DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. [1]

The deregulation of DNMT1-associated lncRNAs contributes to aberrant DNA methylation and gene expression during colon tumorigenesis.

Expression

DACOR1 (DNMT1-associated Colon Cancer Repressed lncRNA 1), shows high, tissue-specific expression in the normal colon (including colon crypts) but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. [1]

Labs working on this lncRNA

  • Department of Genetics and Genome Sciences, Department of Biochemistry.[1]

Reference

  1. 1.0 1.1 1.2 1.3 Merry CR, Forrest ME, Sabers JN, Beard L, Gao XH, Hatzoglou M, et al. DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer[J]. Human molecular genetics. 2015,24(21):6240-53.