CDRT3
Contents
Annotated Information
Name
Approved symbol: CDRT3
Approved name: CMT1A duplicated region transcript 3
HGNC ID: HGNC:14382
RefSeq ID: NR_146601
Characteristics
LeXis, named as "Liver-expressed LXR-induced sequence", it's gene locus Lie in close proximity to the canonical LXR target gene Abca1 in mouse((Sallam T 2016)), was distinct gene with Abca1, almost exclusively located in the insoluble nuclear pellet in fractionation studies, along with the known nuclear lncRNAs XIST and histone H3.
Expression
The highly expressed in primary mouse hepatocytes treated with GW3965((Sallam T 2016)) and upregulated in OS(Osteosarcoma) tissues((Wang G 2017)).
Regulation
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Function
LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism((Sallam T 2016)).
LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth((Wang G 2017)).
Disease
- osteosarcoma
- colon adenocarcinoma [1]
Evolution
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Labs working on this lncRNA
- No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
- Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.
References
- ↑ Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.