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AA174084 long noncoding RNA potentially may play a role during Gastric Cancer development

Annotated Information


AA174084 (also known simply as AA) is a gastric juice long noncoding RNA [1]




lncRNA-AA174084 is a tumor-suppressor gene which was suggested to play a tumor-suppressor role in Gastric Cancer (GC) tumorigenesis (including tumor initiation, progression, metastasis and prognosis) and proposed as a potential biomarker for screening EGC. [2]

Function Mechanism: tumor suppression

Biological Process: pathogenic process

Description: biomarker


AA174084 average expression level in adjacent normal tissues was 3.18 times the average level in GC tissues[2]

Expression levels of AA174084 were down‐regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). [2]


Disease: gastric cancer [2]

Dysfunction type: expression

Description: AA174084 may have potential as marker for the early diagnosis of GC

Labs Working

Department of Biochemistry and Molecular Biology, and Zhejiang Provincial Key Laboratory of Pathophysiology,Ningbo University, China


  1. Virgilio E, Giarnieri E, Giovagnoli MR, Montagnini M, Proietti A, D’Urso R et al. Long non-coding RNAs in the gastric juice of gastric cancer patients[J]. Pathology - Research and Practice. 2018, 214(9):1239-1246.
  2. 2.0 2.1 2.2 2.3 Shao Y, Ye M, Jiang X, Sun W, Ding X, Liu Z et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer[J]. Cancer. 2014, 120(21):3320-3328.