TH2LCRR, which is located at 3' end of the RAD50 gene, the location of TH2-LCR(locus control region) in mice, selectively expressed in primary and effector TH2 cultures relative to primary and effector TH1 and TH17 cultures and functions by binding hnRNPs and WDR5.
TH2LCRR: T helper type 2 locus control region associated RNA (HGNC nomenclature)
It is located at 3’ end of the RAD50 gene, the location of TH2-LCR(locus control region) in mice .
TH2LCR transcript was enriched in the nuclear fraction.
In murine T cells, the TH2LCR is necessary to establish hisone H3K4Me marks at Il4, Il3 and Il5 promoters and distal DNA regulatory elements surrounding these genes.
TH2LCR facilitates the formation of H3KRMe3 marks at multiple genomic positions at IL4 and IL13 loci.
TH2LCR lncRNAs recruit WDR5-containing complexes to regulatory genomic elements(IL4 promoter, IL4 intron and IL4 distal sequence along with the IL13 promoter and two IL13 distal regulatory elements). .
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It is selectively expressed in primary and effector TH2 cultures relative to primary and effector TH1 and TH17 cultures.
It was co-expressed with IL4, IL5, IL13 genes, it is located within RAD50 but was not co-expressed with RAD50.
>gi|827839360|ref|NR_132124.1| Homo sapiens T helper type 2 locus control region associated RNA (TH2LCRR), transcript variant 1, long non-coding RNA
Labs working on this lncRNA
- Department of Medicine, Vanderbilt University School of Medicine, Tennessee 37232, USA .
- Spurlock CF, 3rd, Tossberg JT, Guo Y, Collier SP, Crooke PS, 3rd, Aune TM. Expression and functions of long noncoding RNAs during human T helper cell differentiation[J]. Nature communications. 2015,6:6932.