TFAP2A-AS2:TFAP2A antisense RNA 2
HIPSTR (Heterogeneously expressed from the Intronic Plus Strand of the TFAP2A-locus RNA) is a novel lncRNA gene in the developmentally regulated TFAP2A locus.
HIPSTR promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK293 and in pluripotent H1BP cells predominantly affects the genes involved in early organismal development and cell differentiation.
HIPSTR promoter can be stimulated by TFAP2A, but HIPSTR and TFAP2A are not consistently co-induced in developmental models in vitro.
HIPSTR is a bona fide antisense lncRNA. And HIPSTR has an evolutionarily conserved tissue-specific expression pattern, and that it is predominantly expressed in testis and placenta of mouse (Mouse ENCODE Project RNA-seq data) and of human. In addition, HIPSTR expression in the early human embryo is restricted to a subset of cells.
Labs working on this lncRNA
- Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-000 São Paulo, SP, Brazil.
- Yunusov D, Anderson L, DaSilva LF, Wysocka J, Ezashi T, Roberts RM, Verjovski-Almeida S. HIPSTR and thousands of lncRNAs are heterogeneously expressed in human embryos, primordial germ cells and stable cell lines. Sci Rep. 2016 Sep 8;6:32753.