Approved symbol: SOX1-OT
Approved name: SOX1 overlapping transcript
HGNC ID: HGNC:42733
Previous names: long intergenic non-protein coding RNA 403
Previous symbols: LINC00403
RefSeq ID: NR_120392
LncBook ID: HSALNT0207103
The 5′RACE analysis revealed two main TSS for SOX1-OT located in close genomic proximity to the SOX1 gene, annotated as a long intergenic non-coding mRNA-like transcript with no inferred coding potential, could be detected in human cells, has a complex structure including several unannotated exons, different transcript variants, and at least two potential TSS, a total of 10 exons for human SOX1-OT, 5 of which (exon2, 3, 6–8) are novel and previously unknown, report 9 new SOX1-OT transcript variants (V3–V11) not previously reported in the literature((Ahmad A 2017)).
SOX1-OT was found to be highly expressed in differentiated neural stem cells across different time points of differentiation, and its expression correlated with SOX1 gene expression, different SOX1-OT transcript variants were differentially detected during the course of neural differentiation((Ahmad A 2017)).
Co-expression of SOX1-OT and SOX1 during neural differentiation might indicate a co-regulatory role in pathways regulating neural differentiation((Ahmad A 2017)).
Labs working on this lncRNA
Wolfson STEM Centre, Division of Cancer & Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK((Ahmad A 2017)).
Division of Graduate Entry Medicine & Health, School of Medicine, University of Nottingham, Derby, UK((Ahmad A 2017)).
>NR_120392.1 Homo sapiens SOX1 overlapping transcript (SOX1-OT), transcript variant 1, long non-coding RNA
>NR_120394.1 Homo sapiens SOX1 overlapping transcript (SOX1-OT), transcript variant 2, long non-coding RNA