Disease: gastric cancer (PMID:29902801)
Dysfunction type: regulation
Description: AK058003 is frequently upregulated in GC samples and promotes GC migration and invasion in vivo and in vitro. Next, we identified Î³-synuclein. (SNCG), which is a metastasis-related gene regulated by AK058003. In addition, we found that the expression of SNCG is positively correlated with that of AK058003 in the clinical GC samples used in our study. Furthermore, we found that the SNCG gene CpG island methylation was significantly increased in GC cells depleted of AK058003. Intriguingly, SNCG expression is also increased by hypoxia, and SNCG upregulation by AK058003 mediates hypoxia-induced GC cell metastasis.
Function Mechanism: NA (PMID:29902801)
Biological Process: pathogenic process
Description: therapy target