SMILR

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SMILR (smooth muscle induced lncRNA, enhancer of proliferationas) is a long noncoding RNA that is used as a driver of vascular smooth muscle cell proliferation and consider as a novel therapeutic strategy to reduce vascular pathologies.

Annotated Information

Name

SMILR: Smooth muscle induced lncRNA, enhancer of proliferation (HGNC nomenclature), RP11-94a24.1 [1]

Characteristics

Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm. [1].

SMILR is four exon transcript of 569 bp long noncoding RNA that is located on human chromosome 8q24.13, ~750 kbp downstream of HAS2 on the same (reverse) strand and ~350 kbp from ZHX2 and ~750 kbp from HAS2-AS1 on the opposite strand of chromosome 8 [1]. The longest open reading frame(ORF) within SMILR is 57 amino acids [1].

SMILR is located in both nucleus and cytoplasm [1].

Function

SMILR regulates proximal gene HAS2 in chromosome 8. [1].

SMILR acts as a driver of vascular smooth muscle cell proliferation [1]. Knockdown of SMILR markedly reduced cell proliferation and HAS2 expression was also reduced by SMILR knockdown [1].

Expression

SMILR is expressed highest in heart [1]. It is differentially expressed in human saphenous vein-derived smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor [1]. ​Increased expression of SMILR is observed in unstable atherosclerotic plaques, and plasma from patients with high plasma C-reactive protein [1].

SMILR expression is dysregulated in unstable human carotid plaques [1].

Regulation

SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner [1].

Disease

  • Cardiovascular disease

Labs working on this lncRNA

  • BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
  • British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Ballantyne, M.D., Pinel, K., Dakin, R., Vesey, A.T., Diver, L., Mackenzie, R., Garcia, R., Welsh, P., Sattar, N., Hamilton, G. et al. (2016) Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation. Circulation, 133, 2050-2065.

Sequence

>gi|105375734|ref|NR_131202.1| Homo sapiens smooth muscle induced lncRNA, enhancer of proliferation (SMILR), long non-coding RNA

000001 AAATTCTGTT TCGGTTGCAG TTCCATTGTG TGGAGCCAGT ACTACAACTT TTCCTCCTGC ATTCATTTCT CTTCCTGCTG 000080
000081 CCTTGTGAAG AAGGTGCCTT GCTTCCCCTT CACCTTCTAC GGTGATTGCA AGTTGCCTGA GGATTCCCCA GCCATGTGAA 000160
000161 ACTTTCACAG AGTTTGAGAG AAACTGTATT CAAGTTGCTG AAACCAAGAA GCTACACTCA CGAGTCTCAC CTAAACTCGA 000240
000241 ATCTGATTTA GATGACATCA TCCTGGACTT TGAGTTGATG AAACCTTGGA GGTCTTGGGA GTAAAGCAAG TGTGATTTGC 000320
000321 ATATGATGGA TATGAATTGT AATGGCCAGA GCATGGCTGT GGGAACCAAG ACTGAATTCC ATAATTTACA TGGATGTTTG 000400
000401 GAAGGTGTCT GCAACTTAAT CTGTGTTCGT TTCTGAGATG TTGGGCAACT CCTTCTTGGA AGATGTGGTA ATGGTCTCTT 000480
000481 CGAAAAGAAA ATAATCATCT GAGTTTTGGC CAAAATAGTT GATCGGATTA CCTATGAAAA TGACTCTCAC CCAACTACAA 000560
000561 GAATGTTAT

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Internal error

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[XEX31lV0nQlRmV62rOqVogAAAA8] 2019-01-21 16:48:25: Fatal exception of type "TypeError"

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