SMILR

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Contents

Annotated Information

Approved Symbol

SMILR: smooth muscle induced lncRNA, enhancer of proliferation [1]

RP11-94a24.1 [1]

Chromosome

8q24.13

RefSeq(supplied by NCBI)

NR_131202

Characteristics

SMILR is located ~750 kbp downstream of HAS2 on the same (reverse) strand and ~350 kbp from ZHX2 and ~750 kbp from HAS2-AS1 on the opposite strand of chromosome 8 [1]. The longest open reading frame(ORF) within SMILR is 57 amino acids [1].

Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm. [1].

Cellular Localization

SMILR is located in both nucleus and cytoplasm [1].

Expression

SMILR is expressed highest in heart [1]. It is differentially expressed in human saphenous vein-derived smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor [1]. ​Increased expression of SMILR is observed in unstable atherosclerotic plaques, and plasma from patients with high plasma C-reactive protein [1].

Function

SMILR acts as a driver of vascular smooth muscle cell proliferation [1]. Knockdown of SMILR markedly reduced cell proliferation and HAS2 expression was also reduced by SMILR knockdown [1].

Regulation

SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner [1].

Disease

  • Cardiovascular disease

Labs working on this lncRNA

  • BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
  • British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Ballantyne, M.D., Pinel, K., Dakin, R., Vesey, A.T., Diver, L., Mackenzie, R., Garcia, R., Welsh, P., Sattar, N., Hamilton, G. et al. (2016) Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation. Circulation, 133, 2050-2065.
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