SIX3-AS1:SIX3 antisense RNA 1
SIX3OS has following features:(1) undergoes extensive alternative splicing, with the number of splice isoforms ranging from 1(RaxOS) to 11(Six3OS), (2)shows sequence complementarity, either in human or in mouse, to the mature sense mRNA or to their primary unprocessed transcripts, (3) the degree of sequence similarity between murine and human NATs is very low, with the exception of Six6OS (∼79% identity), and is in general restricted to segments (exons) not exceeding 150 bp in length for each NAT, (4) do not show any open reading frames (ORF) and may therefore represent non-coding RNA transcripts.
RT–PCR experiments carry out on a panel of 10 adult human RNAs demonstrate that the SIX3OS is predominantly expressed in retina with a lower level of expression in the brain or colon in human.
>NR_103785.1 Homo sapiens SIX3 antisense RNA 1 (SIX3-AS1), transcript variant 1, long non-coding RNA
Labs working on this lncRNA
- Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy.
- Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, McInnes RR, Auricchio A, Banfi S. Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet. 2005 Apr 1;14(7):913-23.