SCAANT1

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Please cite: Chunlei Yu (2016) lncRNA: "SCAANT1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=SCAANT1&oldid=1272358 (Last update: Jul 01, 2016). [See details]

SCAANT1, ATXN7 antisense RNA 1, directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter.

Contents

Annotated Information

Name

SCAANT1, SCA7/ATXN7 antisense RNA 1(HGNC nomenclature)

"ATXN7 antisense RNA 1 (non-protein coding)", ATXN7-AS1, "spinocerebellar ataxia-7 antisense noncoding transcript 1"[1]

Disease

Spinocerebellar ataxia type 7

Characteristics

directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter [1].

SCAANT1, a novel antisense ncRNA transcript, located in 3q14.1 [1]

It belongs to the category of "Antisense" in lncRNA classification.

Function

SCAANT1 directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter. [1].

Regulation

CTCF regulates SCAANT1 expression[1].


Expression

Ataxin-7 sense expression and SCAANT1 expression are inversely correlated in human tissues and SCA7 patients[1]

Sequence

>>gi|22919304|gb|BU569004.1|BU569004 AGENCOURT_10400290 NIH_MGC_82 Homo sapiens cDNA clone IMAGE:6616312 5', mRNA sequence

000001 GGTCAGGACG AAGTACCGTG TGCACGCCAC GCCGCCCACA TGTGTGCCCC CGACCCGCAA TTGGAAGTCA CACTGTGCGC 000080
000081 CTGGGGAACT TGAATTCGTC CAGCAAAGAG AGAACATGAG ATCAGTGTGC GAGGGAATGG AGGAGAGTGA AACAAACCGA 000160
000161 GAGAAGCTTT AACCCGTGTA CATATTTTAG AGGCACCACC CCAAGTTTCT GGAAGTGATT CATTCACCCC AAAAGTAAAA 000240
000241 ATCTGATTCA TTTTTANNAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 000320
000321 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAANNNN NNNNAANNNN NNCCAAAAAA AAAAATTNAA AAAANTTTTN 000400
000401 AAAAACAANN NCNAAAAAAA AAAGNNNAAA AAAAATTTAA NTTAAAACGG TGTCCAAAAA AAATTCCCTA GAAAATCCCC 000480
000481 NNNNCTTCTG GTTTTCCCCC GGGAAATCCC ACCCACGGGA ATTCCTCCCG GGGGGTTCCC CAAAAAAAAT CCCAAGAGGG 000560
000561 GGGCCTAAAG AGGCCTTTTC TTGAACACTT TCCCGGAAGG AATTGCCGGG GGAGCTCCAA AAGGGTTTTG TAACCCCGGG 000640
000641 AAAGCCCCGC CCCCCCGGGA ATTAAGGTGA GAATCCGTTT GAAAATTTCT ATAAAAAAGT TGGAGCGCCC CTGCGGAACG 000720
000721 CCTTCATAAG CCCGGGGGGG GGAAAAGGGG AATCCAAAAG GGTTGTGTCC CCCTCCGCGG AACCCCTTTT GGGAATAAAA 000800
000801 GGGTAAAACC GGGGGACAAA AAAATTTTTC ACAAATGGGG CCCCATTGGG GCCAAAATAG GGGTTAATCT CGCCCA

Labs working on this lncRNA

  • Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Sopher BL, Ladd PD, Pineda VV, Libby RT, Sunkin SM, Hurley JB, et al. CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA[J]. Neuron. 2011,70(6):1071-84.
Please cite: Chunlei Yu (2016) lncRNA: "SCAANT1" in LncRNAWiki, available at http://lncrna.big.ac.cn/index.php?title=SCAANT1&oldid=1272358 (Last update: Jul 01, 2016).
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Chunlei Yu2.914129240.9972016-06-29 22:45:31[show]
Contributors with score < 1 are excluded from the authorship.
ContributorContribution Score*Edit Count#Summed Edit QuantityΛAveraged Edit QualityLatest Edit TimeEdit Details
Lin Liu0.0515012016-07-01 22:08:37[show]
Note: For each edit version that is contributed by a specific person, his/her contribution is quantified as its edit quality multiplied by its edit quantity; the edit quantity amounts to the edit distance in comparsion with its previous version (that is, the minimum number of edit operations required to transform one string into the other), and the edit quality corresponds to whether the edit persists in comparison with the last version, ranging from -1, when the edit is entirely reverted (short-lived), to 1, indicating that the edit is totally preserved in the last version (long-lived). Please also note that contribution quantification may take time to reflect recent edits.
*Since one person may perform many discontinuous edits for a wiki page, contribution score is the sum of quantified contributions over all participated edits.
#Multiple successive edits provided by a researcher are counted as one edit.
ΛSummed edit quantity is the sum of edit quantities over all participated edits.
Averaged edit quality is the edit quality normalized over all participated edits.
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