SCAANT1

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SCAANT1, ATXN7 antisense RNA 1, directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter.

Contents

Annotated Information

Name

SCAANT1, SCA7/ATXN7 antisense RNA 1(HGNC nomenclature)

"ATXN7 antisense RNA 1 (non-protein coding)", ATXN7-AS1, "spinocerebellar ataxia-7 antisense noncoding transcript 1"[1]

Disease

Spinocerebellar ataxia type 7

Characteristics

directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter [1].

SCAANT1, a novel antisense ncRNA transcript, located in 3q14.1 [1]

It belongs to the category of "Antisense" in lncRNA classification.

Function

SCAANT1 directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter. [1].

Regulation

CTCF regulates SCAANT1 expression[1].


Expression

Ataxin-7 sense expression and SCAANT1 expression are inversely correlated in human tissues and SCA7 patients[1]

Sequence

>>gi|22919304|gb|BU569004.1|BU569004 AGENCOURT_10400290 NIH_MGC_82 Homo sapiens cDNA clone IMAGE:6616312 5', mRNA sequence

000001 GGTCAGGACG AAGTACCGTG TGCACGCCAC GCCGCCCACA TGTGTGCCCC CGACCCGCAA TTGGAAGTCA CACTGTGCGC 000080
000081 CTGGGGAACT TGAATTCGTC CAGCAAAGAG AGAACATGAG ATCAGTGTGC GAGGGAATGG AGGAGAGTGA AACAAACCGA 000160
000161 GAGAAGCTTT AACCCGTGTA CATATTTTAG AGGCACCACC CCAAGTTTCT GGAAGTGATT CATTCACCCC AAAAGTAAAA 000240
000241 ATCTGATTCA TTTTTANNAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 000320
000321 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAANNNN NNNNAANNNN NNCCAAAAAA AAAAATTNAA AAAANTTTTN 000400
000401 AAAAACAANN NCNAAAAAAA AAAGNNNAAA AAAAATTTAA NTTAAAACGG TGTCCAAAAA AAATTCCCTA GAAAATCCCC 000480
000481 NNNNCTTCTG GTTTTCCCCC GGGAAATCCC ACCCACGGGA ATTCCTCCCG GGGGGTTCCC CAAAAAAAAT CCCAAGAGGG 000560
000561 GGGCCTAAAG AGGCCTTTTC TTGAACACTT TCCCGGAAGG AATTGCCGGG GGAGCTCCAA AAGGGTTTTG TAACCCCGGG 000640
000641 AAAGCCCCGC CCCCCCGGGA ATTAAGGTGA GAATCCGTTT GAAAATTTCT ATAAAAAAGT TGGAGCGCCC CTGCGGAACG 000720
000721 CCTTCATAAG CCCGGGGGGG GGAAAAGGGG AATCCAAAAG GGTTGTGTCC CCCTCCGCGG AACCCCTTTT GGGAATAAAA 000800
000801 GGGTAAAACC GGGGGACAAA AAAATTTTTC ACAAATGGGG CCCCATTGGG GCCAAAATAG GGGTTAATCT CGCCCA

Labs working on this lncRNA

  • Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Sopher BL, Ladd PD, Pineda VV, Libby RT, Sunkin SM, Hurley JB, et al. CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA[J]. Neuron. 2011,70(6):1071-84.
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