Disease: acute myeloid leukemia (PMID:24752773)
Dysfunction type: regulation
Description: RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancers and participates in the orchestration of an intrachromosomal loop. The 3' region of RUNXOR also participates in?long-range interchromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations.
Function Mechanism: NA (PMID:24752773)
Biological Process: pathogenic process