Please input one-sentence summary here.
Four noncoding RNAs from the RAY1/ST7 gene locus. Complex gene locus with a large number of coding and noncoding isoforms. ST7OT1 & 2 are antisense to ST7. ST7OT3 & 4 are on the sense strand. ST7OT1 - ~2kb unspliced antisense transcript that initiates in intron 1 of ST7, covers the first exon and terminates in the ST7 promoter region. Polyadenylated. Nb: it also overlaps exon 1 of ST7OT4. ST7OT2 - Spliced antisense transcripts. Multiple isoforms that share either some 5' or some 3' exons. Isoforms are between 900-1300 bp, with 4-6 exons and polyadenlyated. ST7OT3 - Spliced ~1kb transcript. Begins in intron 10 of ST7, shares exons 11-13 and sometimes 14 & 15 with ST7 plus has a number of unique exons. Some exons may also act as a alternative 3' end for ST7. ST7OT4 - Multiple spliced transcripts within the long first intron of ST7. However, Refseq ST7OT4 transcript may be protein coding. Transcription begins just ~200bp downstream from the end of first ST7 exon.
Please input function information here.
ST7OT1 - abundantly expressed in testis, also expressed in cerebellum, skeletal muscle, uterus, cerebellum, spinal cord, fetal brain, and prostate. ST7OT2 - testis, fetal brain, cerebellum, mammary gland, fibroblasts. ST7OT3 - expression only detected in cerebellum. ST7OT4 - no expression detected.
ST7OT1 - some conserved sequence with mouse, most of this is where ST7OT1 overlaps the first exon of ST7 however. ST7OT2 - 3' end of some isoforms shows some conservation with mouse. ST7OT3 - some conserved sequence, most of this is shared exons with ST7 though. ST7OT4 - sequence not conserved with mouse.
ST7OT1 - NCBI Gene ID: 93653. ST7OT2 - NCBI Gene ID: 93654. ST7OT3 - NCBI Gene ID: 93655. ST7OT4 - NCBI Gene ID: 338069
Please input transcriptomic nomeclature information here.
Please input regulation information here.
Allelic Information and Variation
Please input allelic information and variation information here.
Please input evolution information here.
You can also add sub-section(s) at will.
Labs working on this lncRNA
Please input related labs here.
Predicted Small Protein
|Amino acid sequence||MSYYVDRAGLEFLGSSNPSASTF|