HOXA-AS2, which is located between the HOXA3 and HOXA4 genes in the HOXA cluster, is expressed in both human peripheral blood PMN and in the human promyelocytic leukemia cell line NB4 and plays important roles in the mediation of inflammatory disorders, where apoptosis plays a major role in the resolution of inflammation and prevention of tissue damage.
HOXA-AS2: HOXA cluster antisense RNA 2
HOXA3as: HOXA cluster antisense RNA 2 (non-protein coding)
HOXA cluster antisense RNA 2 (HOXA-AS2) is a long non-coding RNA located between the HOXA3 and HOXA4 genes in the HOXA cluster. 
HOXA-AS2 functions as an apoptosis repressor in ATRA-treated NB4 cells, through mechanisms mediated in part by TRAIL.
Its transcript is expressed in NB4 promyelocytic leukemia cells and human peripheral blood neutrophils, and expression is increased in NB4 cells treated with all trans retinoic acid (ATRA). 
|Primer||Forward primer||Reverse primer|
|Knockdown||HOXA-AS2 shRNA A||acacaccgttagccaatattt |
|HOXA-AS2 shRNA B||ctgttggcagattagatatat |
|HOXA-AS2 shRNA C||ttgtcccattacttaaatcta |
Please input transcriptomic nomeclature information here.
Please input regulation information here.
You can also add sub-section(s) at will.
Labs working on this lncRNA
- Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA. 
- Zhao H, Zhang X, Frazao JB, Condino-Neto A, Newburger PE. HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells[J]. Journal of cellular biochemistry. 2013,114(10):2375-83.
Predicted Small Protein
|Amino acid sequence||MVIIFAVSLSPSLIFMAAVPHKSFRLMSHREMLPRSLTLQWLPPPPWPLSPRFWRSLAPS|