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ncR-uPAR: non-protein coding RNA, upstream of F2R/PAR1
~400 bp. RNA polymerase II transcript. Found several kb upstream of the human protease-activated receptor-1 (PAR-1) gene.
Mostly made up of repeat sequences including an Alu element.
ncR-uPAR can act in-trans to stimulate PAR-1 expression.
ncR-uPAR binds nuclear proteins in-vivo, which could provide a mechanism for it to positively regulate the PAR-1 promoter during embryogenesis.
Expressed during embryonic development.
Presence of the ncR-uPAR promoter sequence drives expression of a transgene during embryonic vascular development at E9, which recapitulates PAR-1 expression at E9 quite well. At E16 expression was seen in brain and in arteries but not veins.
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Refseq ncR-uPAR appears to be the ncR-uPAR promoter and the lncRNA sequence. UCSC genomic co-ordinates are to this Refseq annotation, while the sequence provided is from the identified transcriptional start site to the end of the polyadenylation sites (exact 3' terminus is unknown).
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Allelic Information and Variation
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Labs working on this lncRNA
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