DANCR, an 855-base-pair lncRNA, suppressed differentiation.
DANCR，differentiation antagonizing non-protein coding RNA（HGNC nomenclature)
"anti-differentiation ncRNA", "anti-differentiation noncoding RNA", lncRNA-ANCR
"small nucleolar RNA host gene 13 (non-protein coding)", SNHG13 "adipogenesis up-regulated transcript 2", AGU2
The ANCR gene is located on human chromosome 4, with the closest adjacent annotated genes located 54.8 kb upstream of (USP46) and 28.7 kb downstream from (ERVMER34-1) the ANCR locus. The ANCR locus consists of three exons and harbors a microRNA (MIR4449) and a snoRNA (SNORA26) in introns 1 and 2, respectively. These small RNAs are not coordinately expressed with ANCR and are not part of the mature ANCR transcript). 
It contains another conserved GC-rich region in the first intron, which may be processed as a not-yet-annotated small functional RNA. This notion does, however, require more intensive analysis of the function of DANCR. From an evolutionary perspective, it is of interest that transcription units of DANCR as well as AGD2 are shaped by retrotransposons. AGU2 contains a long terminal repeat (LTR)-like element, which provides its polyA signal.
ANCR suppresses a genetic program associated with epidermal differentiation. Depleting ANCR in progenitor-containing populations, without any other stimuli, led to rapid differentiation gene induction. In epidermis, ANCR loss abolished the normal exclusion of differentiation from the progenitor-containing compartment. The ANCR lncRNA is thus required to enforce the undifferentiated cell state within epidermis
AGU2 induction seen in adipogenesis might be due to cooperative stimulation by Dex and IBMX.
|shANCR (sense sequence)||GCGTACTAACTTGTAGCAA.|
Labs working on this lncRNA
Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA
Kazusa DNA Research Institute, Chiba, Japan
Center for Biological Resources and Informatics
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Kretz M, Webster DE, Flockhart RJ, Lee CS, Zehnder A, Lopez-Pajares V, et al. Suppression of progenitor differentiation requires the long noncoding RNA ANCR[J]. Genes & development. 2012,26(4):338-43.
- ↑ 2.0 2.1 Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1[J]. DNA research : an international journal for rapid publication of reports on genes and genomes. 1995,2(1):37-43.
- ↑ 3.0 3.1 3.2 3.3 Kikuchi K, Fukuda M, Ito T, Inoue M, Yokoi T, Chiku S, et al. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation[J]. Nucleic acids research. 2009,37(15):4987-5000
DANCR,ANCR,"anti-differentiation ncRNA", "anti-differentiation noncoding RNA", lncRNA-ANCR,KIAA0114, "KIAA0114","small nucleolar RNA host gene 13 (non-protein coding)", SNHG13 "adipogenesis up-regulated transcript 2", AGU2