NONHSAT087716

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LINC00312, long intergenic non-protein coding RNA 312, could represent a potential biomarker for metastasis, progression and prognosis in nasopharyngeal carcinoma.

Contents

Annotated Information

Name

LINC00312: long intergenic non-protein coding RNA 312(HGNC nomenclature)

ERR-10, ERR10, "estrogen receptor repressor 10", "LMCD1 downstream neighbor", LMCD1DN, NAG-7, NAG7, "nasopharyngeal carcinoma candidate 7" [1]

Characteristics

LINC00312 is a long intergenic non-coding RNA (lincRNA) located on 3p25.3[1].

Function

LINC00312 expression patterns can distinguish the non-cancerous group from the NPC group[1]

LINC00312 could predict a good prognosis of no lymph node metastasis and a poor prognosis of lymph node metastasis in NPC patients, which indicated that LINC00312 could represent a potential biomarker for metastasis, progression and prognosis in NPC[1].

Regulation

LINC00312 was strongly negatively correlated with EBER-1 in NPC, which suggests that EBER-1 could possibly regulate the expression of LINC00312 through some genes and signaling pathways[1].

Expression

LINC00312 was significantly down-regulated in NPC tissues compared with non-cancerous nasopharyngeal epithelium tissues. Overexpression of LINC00312 inhibits proliferation by arresting cell cycle progression from G1 to S phase and increases the adhesion, motility and invasion of cells, both in vitro and in vivo via the H-ras/p–c-Raf and JNK2/AP-1/MMP1 pathways in NPC HNE1 cells[1].

Diseases

  • nasopharyngeal carcinoma[1]

Labs working on this lncRNA

  • Department of Medical Laboratory Science, Xiangya School of Medicine, Central South University, Changsha, 410013, China.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, et al. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma[J]. Journal of molecular histology. 2013,44(5):545-54.

Basic Information

Transcript ID

NONHSAT087716

Source

NONCODE4.0

Same with

{{{same}}}

Classification

intergenic

Length

2887 nt

Genomic location

chr3+:8613468..8616354

Exon number

1

Exons

8613468..8616354

Genome context

Sequence
000001 TTTTCTTTTG ATAGAATGTC AAACTTACGA AAAAAGTTAC AAGAAGAGAA CAAAgagcta ttagagggtg ttgctgacac 000080
000081 aatgctttat cactcttgaa tattttcgtg tgtaattcct acaaataagg acattctccc acatagccac aatacaacca 000160
000161 tcaaaatcag gaagttaacg ctgatgtgtt tctaccatgt aatcctcaga tccaattcaa gtgtcaccag ctgtcccaat 000240
000241 aatgtctttt ataacaaaaa cattcagtct aagatcactc attctattta gttatcttgt ctattcttca atttggaagt 000320
000321 gttctttgtt ctttcctgaa tgttcatgac cttgacatct tagaagatta aaggttattt aaagttgttg agttaaatat 000400
000401 ccattaaatt aggtttgtca gatatttcct cgaaattaga ttcagcttat gcattttttg gaaggaatac cacagaagtg 000480
000481 atgttgtttt ctttctgttg catccaatca gatgatacag gattttgatt tgttccatta ctgttgacat gaattttgaa 000560
000561 catttgataa tgccagtatc agccagattt ttccattgta aagtcattcc tttgtccttt gtatttaata agtatgttta 000640
000641 gggactttga gactatgtca atgtcctgtt cttcatcaaa attccactca ctcattctta gtattcattg acgtttactg 000720
000721 atcgaactaa ttattattat gatagttgcc aaatgttggt ttttctaatt caatcatttc tttagtgttt attagcattc 000800
000801 tactataagg aaaagcacta tcttctcccc atttattaat tcacatattt acatcagctt ggagttattg atttctattt 000880
000881 tattaaatag tttataattg attaccatcc ttatttattt taatgctcaa attgtcccaa attatggcca aagaaagctc 000960
000961 cttcaaactg gttgctatgt ccttttgaca tggcccatca ttctttaaac acattttaca tctggcacaa taacgtgcta 001040
001041 catacccatc ttgtattttt cctgccccat ctttgaaatc agccattctc aaggggttcc ttcttaatCT GGCTGTTGTT 001120
001121 GTGTTGGAAC TCCTGGTACC ATCTTAGAAC CTTAAGGAGA CAAGCGAACC AAGCCAATAA GCTTTCCATG ATGCTGCTTA 001200
001201 GAGTTAAACA GAGCCCAGGT ACTAAGTTAT GTCATGGAGA CAGTGAACTA ACCTCTGGAC TGCTTGCTAC ATGAGACAAT 001280
001281 TGATTTTCTT ATTTTCTATG TAGGGTGGTA CATTTCCTCA TTTTGAGATA TTTCTTCAAC ATATAGCTTT TCATTAGTGG 001360
001361 GGATTTTGTC AATTATAACC AAAAACAATG TGACGGATAC CCAAGATGTT TCATGTTGTA GCTTGGGTGA ATTACACATT 001440
001441 TCTGAAGCCA TTACACTTCC TAGTTTATTT GGAtttaagt tgacaaataa aaattgcata tgtttatggt ctataacatg 001520
001521 gtgtttcgat atatgtatac atcgtggaat ggctaaatca agctaacata tccattacct cacatagtta ttttttgtgg 001600
001601 tgagaacatt ttaaaaatat tgtcttagca attttcaaTC AAGCCTGTCC CATGGAGACA CAAGCAATAG TGACATGAGC 001680
001681 ACTTGACTCG CTGGGTTATC AGGCTTTGGC TCCAAATGTT TGGCTTCAAA TATGAAAAAG TTACATGAAA GATGAAACTA 001760
001761 TGCAATGGCA TGGCTGTTGG TCATTCACAT CTCTCTCTGC CAAGAATGGG GATGACGCTG TTGAAGGAAG AAATGTGTTT 001840
001841 TCTCCTTTTT CTCAAGTGAT ATTTGCCTTA GGTCAGATTC TACTAGTTTA AAGCAAAACG ATCTCCTGGT CTGATTCCTT 001920
001921 TGGGTCTCTA ATAATGGAAA CTGCAAGGAT CAGCATAAAG TGTTCCTTTG TTCTGACGTT GGTATAACAT TGCTTCTTGA 002000
002001 AAAATGAAAG TATTTGGACA TACAGACAGA AGCAAtatta ttcaggtctt ccttgttgca agtgagggaa atccaattaa 002080
002081 aactggttta aacctaaaaa aaaaaaAAAG AAGAAAAGAA AAGAAAAAAT ATGAGAGGGG TTTTGCTTTC TGGAATCTGC 002160
002161 TTTCTAGTCA Gaaagtgcag aagaagggct agcttcagga acaattggat gcagtagttc aaatcacaag ttaagtctct 002240
002241 gcttcttttc tccatctctc ttctgtcttc ctccacactg gctttattct taggtaggct tacccagata gtcataaaca 002320
002321 cagccaccag tggcagctgg gctcactttt gtccttggag ccagtgagcc catgaaaaag gagcttctct ttctggagct 002400
002401 tcccaggggt aactttgatc agccaacaag ggtcagtcct atgcttatcc cttgaccaat ctctgtgccc agagggcagg 002480
002481 gtactctgat tggcaatacc ttcatcgtgg gccaaccact gtggggaagg gggagggatt agaaaagaca gccacaccca 002560
002561 aatctcatga aGCAGTCCCC TTTATTTTAA AAAAGTCCCT GTGAGAGCAA CAGGAGCAAA GCATGGAGAA GAAGCAATCT 002640
002641 TGGAGAAGCT GGAAGAGAAC TGACCCAAAG AATCCAAGAG ACTAAGACTG TGCAGGGTTG GGGAACGGAA GCTCACACAG 002720
002721 GAGGCCTGGA CAGAGCTGCA GCAGAGCCAG GAGAGAAGCC AAGTGGCACA GCTCATCTTG AAGTAATTAT AATGCCACTA 002800
002801 AAATTCTCAT TTGTATTAAT TTTTTTTAAT TACTGGCAAG ATAAGGCAAA TGTTTTTAAA GGCCTAAATA AAATGATATT 002880
002881 CCCTGAA
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