Approved symbol: EGOT
Approved name: eosinophil granule ontogeny transcript
HGNC ID: HGNC:37129
Previous names: eosinophil granule ontogeny transcript (non-protein coding)
Alias symbols: EGO; NCRNA00190
Alias name: eosinophil granule ontogeny; non-protein coding RNA 190
RefSeq ID: NR_004428
LncBook ID: HSALNT0288940
Two isoforms: ~1.0kb unspliced EGO-A and ~1.5 kb spliced (two exons) EGO-B.
Transcribed antisense from a conserved intron of ITPR1 gene.
Proposed to affect myeloid development by regulating eosinophil gene expression, as knockdown of EGO in vitro in CD34+ cells decreases eosinophil granule protein MBP (major basic protein) and EDN (eosinophil derived neurotoxin) mRNA levels.
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Highly expressed in human bone marrow CD34+ cells and BMMC (bone marrow mononuclear cells). Highly upregulated during eosinophil development from CD34+ human hematopoietic stem cells before returning to basal levels within 72 hours. Despite a return to basal levels, EGO transcripts were present and inducible in mature eosinophils.
EGO and some of surrounding sequence is conserved. However the presence of EGO has not been investigated outside of humans.
The whole EGOT locus contains several evolutionary conserved, and thermodynamic stable secondary structures. The spliced isoform, EGO-B, is highly conserved and may be present throughout the placental mammals.
Labs working on this lncRNA
- Bioinformatics Group, Department of Computer Science, University of Freiburg Freiburg, Germany.
- Xu, S.P., Zhang, J.F., Sui, S.Y., Bai, N.X., Gao, S., Zhang, G.W., Shi, Q.Y., You, Z.L., Zhan, C. and Pang, D. (2015) Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer. Tumour Biol, 36, 9807-9812.
- Rose, D. and Stadler, P.F. (2012) Molecular evolution of the non-coding eosinophil granule ontogeny transcript. Front Genet, 2, 69.
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