MIR155HG, a 1500 bp long non-coding RNA transcribed from BIC(B-cell integration cluster).
"B-cell receptor inducible", BIC, "BIC transcript", NCRNA00172, "non-protein coding RNA 172"
MIR155HG, encoding a 1500 bp non-coding RNA, is comprised of three exons and locates in cytoplasm.
MIR155HG, as a T cell early activation proto-oncogene, might act to alter the genetic program, such that upon antigen re-stimulation.
MIR155HG promoter may be activated by both AP-1- and NF-κB-mediated mechanisms upon B-cell stimulation.
- B-cell chronic lymphocytic leukemia, Breast cancer 
MIR155HG expression is highly induced by antigen receptor stimulation of B-cells (i.e. B-cell receptor cross-linking) 
Labs working on this lncRNA
- Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.
- First Faculty of Medicine and Center of Experimental Hematology, Charles University in Prague, Prague, Czech Republic.
- Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.
- ↑ 1.0 1.1 1.2 1.3 Elton, T. S., H. Selemon, S. M. Elton, and N. L. Parinandi. "Regulation of the Mir155 Host Gene in Physiological and Pathological Processes." Gene 532, no. 1 (2013): 1-12.
- ↑ 2.0 2.1 Haasch, D., Y. W. Chen, R. M. Reilly, X. G. Chiou, S. Koterski, M. L. Smith, P. Kroeger, K. McWeeny, D. N. Halbert, K. W. Mollison, S. W. Djuric, and J. M. Trevillyan. "T Cell Activation Induces a Noncoding Rna Transcript Sensitive to Inhibition by Immunosuppressant Drugs and Encoded by the Proto-Oncogene, Bic." Cell Immunol 217, no. 1-2 (2002): 78-86.
- ↑ 3.0 3.1 3.2 Vargova, K., N. Curik, P. Burda, P. Basova, V. Kulvait, V. Pospisil, F. Savvulidi, J. Kokavec, E. Necas, A. Berkova, P. Obrtlikova, J. Karban, M. Mraz, S. Pospisilova, J. Mayer, M. Trneny, J. Zavadil, and T. Stopka. "Myb Transcriptionally Regulates the Mir-155 Host Gene in Chronic Lymphocytic Leukemia." Blood 117, no. 14 (2011): 3816-25.