NONHSAT081499

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MIR155HG, a 1500 bp long non-coding RNA transcribed from BIC(B-cell integration cluster).

Contents

Annotated Information

APPROVED NAME

MIR155 host gene

APPROVED SYMBOL

MIR155HG

SYNONYMS

"B-cell receptor inducible", BIC, "BIC transcript", NCRNA00172, "non-protein coding RNA 172"

Characteristics

MIR155HG, encoding a 1500 bp non-coding RNA, is comprised of three exons and locates in cytoplasm.[1]

Cellular Localization

  • Cytoplasm

Disease

Chronic lymphocytic leukemia [2]

Function

MIR155HG, as a T cell early activation proto-oncogene, might act to alter the genetic program, such that upon antigen re-stimulation.[3]

Regulation

(A) Schematic representation of the human MIR155HG with the transcription factor binding sites which have been shown to regulate the expression of this gene which have been localized downstream of exon 1. (B) Schematic representation of the transcription factor binding sites which have been shown to regulate the expression of MIR155HG which have been localized upstream and just downstream of exon 1. The black arrow in exon 1 denotes transcription initiation. The light blue shaded area represents a CpG island. TATA represents the location of the TATA box for MIR155HG.[1]

MIR155HG promoter may be activated by both AP-1- and NF-κB-mediated mechanisms upon B-cell stimulation[1].

Diseases

  • B-cell chronic lymphocytic leukemia, Breast cancer

Expression

MIR155HG expression is highly induced by antigen receptor stimulation of B-cells (i.e. B-cell receptor cross-linking) [2]

Labs working on this lncRNA

  • Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.[1]
  • First Faculty of Medicine and Center of Experimental Hematology, Charles University in Prague, Prague, Czech Republic.[2]
  • Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.[3]






References

  1. 1.0 1.1 1.2 1.3 Elton, T. S., H. Selemon, S. M. Elton, and N. L. Parinandi. "Regulation of the Mir155 Host Gene in Physiological and Pathological Processes." Gene 532, no. 1 (2013): 1-12.
  2. 2.0 2.1 2.2 Vargova, K., N. Curik, P. Burda, P. Basova, V. Kulvait, V. Pospisil, F. Savvulidi, J. Kokavec, E. Necas, A. Berkova, P. Obrtlikova, J. Karban, M. Mraz, S. Pospisilova, J. Mayer, M. Trneny, J. Zavadil, and T. Stopka. "Myb Transcriptionally Regulates the Mir-155 Host Gene in Chronic Lymphocytic Leukemia." Blood 117, no. 14 (2011): 3816-25.
  3. 3.0 3.1 Haasch, D., Y. W. Chen, R. M. Reilly, X. G. Chiou, S. Koterski, M. L. Smith, P. Kroeger, K. McWeeny, D. N. Halbert, K. W. Mollison, S. W. Djuric, and J. M. Trevillyan. "T Cell Activation Induces a Noncoding Rna Transcript Sensitive to Inhibition by Immunosuppressant Drugs and Encoded by the Proto-Oncogene, Bic." Cell Immunol 217, no. 1-2 (2002): 78-86.
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