NONHSAT076558

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GPR1-AS is a novel imprinted gene that is expressed from a paternal allele in the human placenta

Contents

Annotated Information

Name

Relative expression of GPR1AS and Zdbf2linc in multiple human and mouse tissues (qRT-PCR)[1]

GPR1-AS:GPR1 antisense RNA (HGNC nomenclature)

"G protein-coupled receptor 1 antisense RNA", GPR1AS[1]

Function

Epigenetic regulation mechanisms in the imprinted GPR1-GPR1AS-ZDBF2 region were well-conserved betweenhuman and mouse genomes without the high sequence conservation of the intergenic lncRNAs. LncRNAs with highly conserved epigenetic and transcriptional regulation across species arose by divergent evolution from a common ancestor, if they do not have identical exon structures.[1]

Expression

GPR1AS/Zdbf2linc is exclusively expressed in human/mouse placenta with paternal-allele-specific expression and maternal-allele-specific promoter methylation (GPR1/Gpr1 DMR)[1].

GPR1AS/Zdbf2linc is rarely expressed throughout post-gastrulation development and into somatic tissues due to bi-allelic hypermethylation at their transcription start sites[1].

Labs working on this lncRNA

Department of BioScience; Tokyo University of Agriculture; Tokyo, Japan[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, et al. Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc[J]. Epigenetics : official journal of the DNA Methylation Society. 2013,8(6):635-45.

Basic Information

Transcript ID

NONHSAT076558

Source

NONCODE4.0

Same with

GPR1-AS,GPR1AS,"G protein-coupled receptor 1 antisense RNA"

Classification

antisense

Length

1343 nt

Genomic location

chr2+:207128708..207130050

Exon number

1

Exons

207128708..207130050

Genome context

Sequence
000001 ACTCCAGCCT GGGCAACAAG AGTGAAACTC TGCCTCGGAG GGAAAAAAAA AAAAAAAGAA TTGAAAGAAT GAAAACCTGT 000080
000081 CCTCAATGTG CCTGAATAAA TGCTTGTTCA GACACTGGAT GTGAAGTCCG ATTCTCCACT GGATACCCAA ACTGCAGGAG 000160
000161 GTAGGTGGTT CCCATCTGGA CCCGAGTTGC CTACCAGACC ATTGTCAGAA ACACAGCTGG ACGTGAGTTA AAGTGGTGAA 000240
000241 AAAACAGATT TTATTCAGTA ACTACTGAAA GTAGGGAAGG AGCTGAGCTT ATTCCGATTT CGGCAGAGGT GATTTGGGTG 000320
000321 TTTTAAAGAA AGAATGAGGG AGACGGGAAT AAAGGAGCTC CGAAGTGTCG GGGAAGTGAA AAAGTGCAAA GGGGAGCTTC 000400
000401 CGGATAGCGA AGCACGTGGA GGTTCCTGGA GGGTGTCCTC CCAGAGAGGA CGTGGAACCT TCCCGCTCCC ACCGCGCACT 000480
000481 TGCCCTGTGT ATCTCTTCCC TTTGGCTGTT CATCTACATA CGTGGTAGTT TCCTTTATAG TAAACTAATA AACGGAAATT 000560
000561 TGCAGCAGCT GTGAAAAACT TCAATTTTCT GAATCCACTT TTGATTTTTA GTGGCGATTG CTTAAATGCC TCAGTTTTAA 000640
000641 GTATCATAAC GAAAGGAAAG CATACGATTC CTATATTAAT GAATCGGAAG TACCTTTTGC AGTTTTTGTT TTGCTTTTTC 000720
000721 AGACAAGGTC TTATTCTGTC ATCCAGGCTG GAGTGCATTG GTGGGAACAC AGCTCACTAC CTACTCAGCC TCCTGAGCTC 000800
000801 AAGCGATCCT CCCACCTCAG CCTCTCAAGT GGCTAGGACC ACAGGCACCC ACGCACTACA CCGCCTAACT AATGTTTTGT 000880
000881 TTTATATTAT ATTATTTTAT TTTATAGAGA CAGAGGTCTC ACCATGTCGA CCAGGCTAGT TTTGAACTCC TGGCCTCAAG 000960
000961 CAATCCTCCT CCCACCTCAG CCTCCCAAAG TGCTAAAATG ATAGGTGTGA GCCACTGCAC CCGGTGATTT TGCAGTTTTT 001040
001041 GGAAACCACA AGTTTGATTT CGGTGTGAAT ATTTTGGAAG AATCTATGAA ACAAATGCAC TTCATCTGAT TTCTCAGTAA 001120
001121 TGTTGATGAT AGATTTACTT CTGAACCTCT TGGACGTGTG TATGTTAGAA GTTCTCCACC CAATTGATAC GGAATTAAAT 001200
001201 AGCTGTGAAA TTACTGTAAG AAGAACCGAA GCAACGTTGG AAATTTGGTA ACTAATGCCA CGTTGGAAGC TATTCATGCC 001280
001281 AATGTAGCAT TGCTTCATAC AGGTACTTCC AGATCTAATT GAATACATCC AGTGGGAAAT TTC
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