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Zeb2NAT: Zeb2 natural antisense transcript
>1.2 kb; antisense to Zeb2 (a transcriptional repressor of E-cadherin) (Nelles (2003)).
Controls translation and therefore function of the Zeb2 protein coding gene through regulation of Zeb2 mRNA splicing (Beltran (2008)). Zeb2 translation requires retention of an intron, Zeb2NAT overlaps the 5' splicing site of this intron and when expressed inhibits splicing allowing translation of Zeb2 (Beltran (2008)). Snail1 acts to stimulate Zeb2 synthesis via post-transcriptional regulation which appears to be mediated by Zeb2NAT (Beltran (2008)).
Expression is upregulated by Snail1 (Beltran (2008)).
Good conservation between human and mouse (Nelles (2003)).
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Allelic Information and Variation
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Labs working on this lncRNA
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