NONHSAT033821

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BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma.

Contents

Annotated Information

Name

DLEU2,deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature)

LEU2, LINC00022, "long intergenic non-protein coding RNA 22", "mir-15a-16-1 cluster host gene (non-protein coding)", MIR15AHG, NCRNA00022, "non-protein coding RNA 22", TRIM13OS[1]

Function

DLEU2 are strong candidates as tumor suppressor involved in B-CLL leukemogenesis[1]

Expression

Expression analysis of the BCMSUNL gene [1].

As expected, in patients with bi-allelic loss of 13q14.3, BCMSUN expression was reduced markedly.[1] Residual amounts of BCMSUN expression likely represent gene expression in non-tumor cells, which were present in the range of 2% to 15% in the tumor specimens.[1]

Allelic Information and Variation

Apart from the distinct 3′end(74 bp),BCMSUNL shares 90.3% homology with the sequence of BCMSUN. Due to the lack of introns, the BCMSUNL transcript cannot be spliced, whereas RT-PCR with appropriately selected primers detected BCMSUN transcripts lacking exons 2 and 6, as reported previously,indicating the existence of respective splicing variants.[1]

Labs working on this lncRNA

  • Abteilung "Organisation komplexer Genome", Deutsches Krebsforschungszentrum, Heidelberg, Germany[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Dohner H, et al. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like[J]. International journal of cancer Journal international du cancer. 2000,88(5):692-7.

Basic Information

Transcript ID

NONHSAT033821

Source

NONCODE4.0

Same with

DLEU2 ,LEU2

Classification

intergenic

Length

2440 nt

Genomic location

chr13+:50656307..51102670

Exon number

6

Exons

50656307..50656693,50730963..50732212,51007549..51007686,51066787..51066897,51102002..51102200,51102316..51102670

Genome context

Sequence
000001 GCACATGCGC AGAATCATCG TGGTGCACGG CTCTCCCTTT GCTTCTTCGG TTGCAGTCCT CTTGCTTCTT GCGCGTGCGT 000080
000081 GTAGCGCTTT TGCAAAGCCG CGGAGGTGAA GTGAACTTAG AGGTTGTGGG GCCGAGGGGT CGTCTTATAG CTACCAGCCC 000160
000161 ACAGGCATTT AGTCTACGTT GGAGGTAAAC AAATACGGGT CCTGCTTAGG AGAAAAGAAA AACGTCTTAC AGCCAGTGTC 000240
000241 TAAACTCCAA ACAACGGAAT GTATCAATGA GACCTTGTAT ATGGATACAC GTGCATTTAA AACCGCCCTG CCGGCttgta 000320
000321 gagcttttgc cgttctccag cgctttacag gggttatcgc acttaagcct cggaacaact ttaccagATT CAGCTGGCTA 000400
000401 CCCCACTTGG CTACAGAGTA CTAAAGAAGA GACTGAACTT GATCCTGCTG CCCTTGCATA CACAACACTC CCATTGACGC 000480
000481 TAGTGAAGAC TTAAGCGCAT GAAAGGATTC CAGGATCAAA AGGTTAGCTC TATGGGGAGC TGTGTCTGGC TCAAGCAATC 000560
000561 CATTTTTTTC TATTGACAGT GAAAACGTTT TATAGTTCTT TTTCAAAGTT TTCCCAAACT TTTACAATAA CAGGCAACTT 000640
000641 GTGAAAAAGT GAGAAGGCAT CTAATTGAAC TATATCCAGA GGAGATCATG GCAGAGACCA ACAGGAAGAA AAACATTTCC 000720
000721 AAACCACAGC GATATTGGTC AAATCAATTG TATTTGAAGA ATAAAGCATT TGAGGCGTCG GCTGAGAAAA ATTTTCATTA 000800
000801 TGAAACTTGG TTGGACTATG AAGCAGAATG TGAGATAAAA TAAAACACAG AGCTCATGAG TTTTTATCTT TGTCTGCTAA 000880
000881 TGACTTATGC TAGCAGGATT ATACTTTTTT TTTGCATTTT ATGAGATGTA TGAACTAGGA AGAAAATACA TGCTATATCT 000960
000961 AAATGGATTA GACGTGCAGA TTCTTAACTA ACATTTAATT CATTGCTAGT AAAACAAATG CCTTAAAACA TTTAAAAAAG 001040
001041 TGAAATTATC TTAAGGAGAT AATTAACAAG CAGAGTAGAA TAGCATTTTT GAAGAAAGTG TAATATGGTT CTACACTGGC 001120
001121 ATTTTCTGCA TTTATTGAAG ATACTTAGTC TATCCAACAA TTCACTCATT CATTCTTTCA tgaaaccctg tctctactaa 001200
001201 aaatacaaaa aaaaattagc tgggcacggg ggtaggccct tgtagtccca gctactcggg aggctgaggc aggagaatgg 001280
001281 cgtgaacccg ggaggcagag cttgtagtga accaagatcg cgtcactgca ctccagccta ggtgacagag cgagactccg 001360
001361 tctcaaaaca acaacaacaa caacaacaac aacaacaaca acaacaaATT TCTTTGTGCA CTTACTATAT GCCCAATGCT 001440
001441 AATCTAATAG TTTTACAAGA CCTCAATTGA ACAAGTGTCT GAGGAAATGG ATTGCATCTA ATAAAGCAAG ACACACCAAC 001520
001521 TGTGGATGGG TGGTGTGTCT AGAGTATTTT GCATTCCTAA ATCACTCTTC TGGAGAAAAT TTGTATCAAT AATTTTGTCT 001600
001601 AGCTTCACCT GGAGTTACAC ATTTTGATTG GTAAGTGttg ctctggctat atcaaataaa agtgtcaaga gtgagcatcc 001680
001681 ttgccttgtg ctgaatcaca aaggaatacc tttcagtttt tctccattga ttatgatagc agtgggcttt tcacagtggg 001760
001761 ctttactgtg ttgagGTACC CTAATGACAA GTTCACCCCA GTGTTTTCTG AGGAGTCTAC CTGGAAATGA GAACCATCTG 001840
001841 TCCTTCCTAT AGTAGTTCTT CTCAGAATGC CGACTCTATG CTAATGGAGG AGGTCTGATG GCCGGGAGGA CAGGAAGAAG 001920
001921 GAACCCACAA TGAAGCAAAA GTTGCGTTTA ACTCTGTCCT CACCATTCCT CTCCTGGACC TGTCCTAAAC TGGAAGCTGG 002000
002001 GGGAGGATGG AGTGCTGGAA TGCTGCAGAA GTCTCATGGG AGGGCGCCTG GTGTTCACCA CATGTGTACA CTGTTGCACG 002080
002081 ACCAGATGGA AATTTGAATG CTGGGGCTCA GTGGAACACC TGAAGGAAGC TGGTGAGGCA GATGTCCCGC TATGCCTTCC 002160
002161 AAGTGTCATG CAACCAGTTC ATGCCTGTCA GCATCTCTGC CGGTGGACTC TGTGAGTCAG CAAATCTACA GAGCAGAGAG 002240
002241 CCACAAGTGG GGACAGATGT GGTCAAATGC CATTTAAATC AGTGATTCTC AACCCAGGAG TTGTCATGGC ACTGGCCTTG 002320
002321 AGTGAGCTGG ACCAAGGGAA GTGGTAGAAT TCCCCATGAA GGACCAAGTG AGCAGATAGA AGTTTCTCCA TTTTAACTTT 002400
002401 TTCTGAGTCA ATTTAAAAAA CACCTAGTGC CTTTTTCTGT
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