DLEU1 maps to a critical region at chromosomal band 13q14.3 which is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL).
DLEU1:deleted in lymphocytic leukemia 1 (non-protein coding)(HGNC nomenclature)
BCMS, “deleted in lymphocytic leukemia, 1”, DLB1,"B-cell neoplasia-associated gene with multiple splicing", BCMS1,LEU1, LINC00021, "long intergenic non-protein coding RNA 21", NCRNA00021, "non-protein coding RNA 21", XTP6
DLEU1: deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature)
DLEU1 or DLEU2 exert their function by binding to chromatin, but rather regulate the neighboring cluster of candidate tumor suppressor genes by divergent transcription 
It was regulated by DNA-methylation and histone modifications.
Both lncRNA genes DLEU1 and DLEU2/Alt1 were upregulated in Jurkat cells upon DNA-demethylation in-vitro , underlining that their transcriptional activity depends on levels of DNA-methylation.
hematopoietic and solid tumors
Labs working on this lncRNA
Abteilung Organisation Komplexer Genome (H0700), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Cooperation Unit "Mechanisms of Leukemogenesis," University Ulm, German Cancer Research Center, DKFZ, Heidelberg, Germany.
- Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, et al. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB[J]. PLoS genetics. 2013,9(4):e1003373
- Wolf S, Mertens D, Schaffner C, Korz C, Dohner H, Stilgenbauer S, et al. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions[J]. Human molecular genetics. 2001,10(12):1275-85.
- Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grander D, et al. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia[J]. Oncogene. 1997,15(20):2463-73.
DLEU1,BCMS, “deleted in lymphocytic leukemia, 1”, DLB1',"B-cell neoplasia-associated gene with multiple splicing", BCMS1,LEU1, LINC00021, "long intergenic non-protein coding RNA 21", NCRNA00021, "non-protein coding RNA 21", XTP6