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PR antisense transcripts
Found several antisense transcripts which initiate in the progesterone receptor (PR) promoter region. AT1 and AT3 were unspliced. AT2-T47D and AT2-MCF7 were spliced with seven exons and transcribed over a 70kb region. AT2 isoforms initiated between the PR A and B start sites, had different (cell line specific) start sites but were otherwise identical. AT2-T47D ~1.35kb. AT2-MCF7 ~1.5kb.
Expression identified in human breast cancer cell lines (MCF7 and T47D). AT2 isoforms were the most highly expressed antisense transcripts. AT2 isoforms could be detected in the nucleus.
All function characterisation was on the AT2 isoforms. PR antisense transcripts act as a scaffold for other RNAs and proteins to bind, allowing them to regulate transcription of the progesterone receptor. Different small RNAs targeted at PR antisense transcripts can activate or repress PR transcription. A PR antisense transcript was necessary for activating PR transcription via a small RNA. PR antisense transcripts could associate with small RNAs, Argonaute proteins and hnRNP-k to bring about regulation of the PR protein coding gene.
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Allelic Information and Variation
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Labs working on this lncRNA
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