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TncRNA: trophoblast noncoding RNA.
TSU: trophoblast STAT utron (untranslated region of an mRNA).
~480 nuc (Peyman (1999)), independent transcript from the 3' end of the Neat1 short isoform/MEN epsilon.
Contains a number of sequence motifs that match binding sites for proteins involved in cytokine signalling which up-regulate MHC genes (Peyman (1999)).
Suppressed induction of MHC class II antigens by interferon gamma and partially blocked constitutive and interferon gamma induced expression of MHC class I antigens and ICAM-I (Peyman (1999), Geirsson (2003))
Suppressed major histocompatibility (MHC) class II expression in-vitro through inhibition of class II transactivator (CIITA) promoters (Geirsson (2003), Geirsson (2003), Geirsson (2004)). Also bound STAT1 and reduced its nuclear translocation (Peyman (1999)), contributing to suppression of MHCII and I in human trophoblast cells and hence preventing a deleterious maternal immune response to placental invasion of the uterine wall.
Note: While STAT1 binds the CIITA promoter, it's binding did not appear to be affected by TncRNA, which acted on an area with no known transcription factor binding sites (Geirsson (2003)), so the mechanism is unclear.
Expressed exclusively in the placenta and pancreas while full length Neat1 is expressed ubiquitously. Placenta was the only tissue where TncRNA predominated (Peyman (1999)).
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This transcript comes from the very 3' end of the Neat1 short isoform. It is therefore part of Neat1 but as described above appears to be expressed independently with a function different to that of the full length transcript.
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Allelic Information and Variation
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Labs working on this lncRNA
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