PRINS Psoriasis associated non-protein coding RNA induced by stress is involved in psoriasis susceptibility, plays a role in cellular stress response and regulation of apoptosis .
PRINS: Psoriasis associated non-protein coding RNA induced by stress (HGNC).
PRINS is ~3.6 kb long noncoding RNA and located at human Chromosome 10p12.1 (HGNC) .PRINS contains two Alu elements, as well as also contains a heatshock element that displays approximately 70% similarity to G8, a cytoplasmic noncoding RNA in Tetrahymena thermophila, that is responsible for developing thermotolerance .
Elevated PRINS expression in the epidermis is suggested to contribute to psoriasis susceptibility by disrupting the signal transduction events mediating the genes involved in apoptosis regulation such as G1P3 . In keratinocytes PRINS regulates the expression of the G1P3 gene, an anti-apoptotic protein that is overexpressed in psoriasis .
PRINS is essential for the survival of keratinocytes under stress conditions .
PRINS is expressed in various human tissues with great variability in the level of expression. Interestingly, the level of expression differed to a great extent in different organs. The lowest level of PRINS RNA was detected in cardiac muscle, whereas the highest level was seen in veins. The level of expression was 18-fold higher in veins than in cardiac muscle .
PRINS is overexpressed in psoriatic epidermis. Regulated by the proliferation and differentiation state of keratinocytes . Several stress signals such as ultraviolet-B (UV-B) irradiation, viral infection (herpes simplex virus), and translational inhibition increased the RNA level of PRINS as well as HaCaT keratinocyte cell treatment with microbial agents such as bacteria peptidoglycan, lipopolysaccharide (LPS) and wall extract .
|Experiment||Forward primer||Reverse primer|
PRINS is regulated by the proliferation and differentiation state of keratinocytes .
Labs working on this lncRNA
- Department of Pathology, University of Szeged, Szeged, Hungary. 
- Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary. 
- Department of Dermatology and Allergology, University of Szeged, Szeged, Koranyi fasor 6, 6720, Hungary. 
- Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged 6720, Hungary. 
- Hombach S & Kretz M. The non‐coding skin: Exploring the roles of long non‐coding RNA s in epidermal homeostasis and disease[J]. Bioessays. 2013, 35(12):1093-1100.
- Sonkoly E, Bata-Csorgo Z, Pivarcsi A, Polyanka H, Kenderessy-Szabo A, Molnar G et al. Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS[J]. Journal of Biological Chemistry. 2005, 280(25):24159-24167.
- Szegedi K, Sonkoly E, Nagy N, Németh IB, Bata‐Csörgő Z, Kemény L et al. The anti‐apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non‐coding RNA, PRINS[J]. Experimental dermatology. 2010, 19(3):269-278.
- Bari L, Bacsa S, Sonkoly E, Bata-Csörgő Z, Kemény L, Dobozy A et al. Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells[J]. Archives of dermatological research. 2011, 303(10):745-752.
>ref| AK022045.1| Homo sapiens psoriasis associated non-protein coding RNA induced by stress (PRINS), long non-coding RNA
Predicted Small Protein
|Amino acid sequence||MWPVFFQGRPAVSTVAEMVPSSHTPTQACICALMWLSLEEGSSSLFLFSLFHYRISHFLG|