NONHSAT008995

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BLACAT1,also named linc-UBC1 (Up-regulated in bladder cancer 1), which regulates histone modification status of target genes by physically associating with PRC2 complex.

Contents

Annotated Information

Transcriptomic Nomenclature

BLACAT1:bladder cancer associated transcript 1(non-protein coding)(HGNC nomenclature)

linc-UBC1, LINC00912, "long intergenic non-protein coding RNA 912", "long intergenic noncoding RNA up-regulated in bladder cancer"[1]

Cellular Localization

Nucleus[1].

Function

linc-UBC1 physically associates with PRC2 components EZH2 and SUZ12. [1]

Linc-UBC1 physically associates with PRC2 complex and regulates histone modification status of target genes, which serves as a negative prognostic factor for lymph node metastasis and survival in bladder cancer patients.[1].

Diseases

  • Bladder cancer

Expression

BLACAT1 is frequently overexpressed in bladder cancer tissues compared with normal adjacent tissues[1].

Primers for qRT-PCR Forward Reverse
linc-UBC1 (lincRNA:chr1:205404014-205407007) 5’-CCTGCTTGGAAACTAATGACC-3’ 5’-AGGCTCAACTTCCCAGACTCA-3'[1]
lincRNA:chr10:4692376-4720283 5'-CGAGATGGAGCAAAGGATAAACG-3' 5'-TCAGGGCCAGGAGGTGACTGGA-3'[1]
lincRNA:chr18:37236595-37243620 5'-GTTACCCTTGCCCTTTGGATG-3' 5'-GCCTTGTAGGCCCTCACAGAC-3'[1]
lincRNA:chr4:15669186-15683175 5'-GGCCAGGACGCTGGTTCAT-3' 5'-TCGGGAGGTTGTGGGAGGA-3'[1]
GAPDAH 5’-GAAGGTGAAGGTCGGAGTC-3’ 5’-GAAGATGGTGATGGGATTTC-3’[1]
EZH2 5'-AATCAGAGTACATGCGACTGAGA-3' 5'-GCTGTATCCTTCGCTGTTTCC-3'[1]
SUZ12 5'-TTGCAGCTTACGTTTACTGGTT-3' 5'-GGAACTTGCCTTATTGGACAACT-3'[1]

Labs working on this lncRNA

  • Department of Urology, Sun Yat-sen Memorial Hospital, 107th Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong province, PR China. [1].

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, et al. linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer[J]. Biochimica et biophysica acta. 2013,1832(10):1528-37.

Basic Information

Transcript ID

NONHSAT008995

Source

NONCODE4.0

Same with

BLACAT1,Linc-UBC1

Classification

intergenic

Length

2616 nt

Genomic location

chr1-:205404014..205425214

Exon number

2

Exons

205404014..205406459,205425045..205425214

Genome context

Sequence
000001 GTGCGCCCCG TGCTAACCCA TTGAAGAATA ATTATTTTTC TCCACTGGAA GCTACAGCAG AGAATCGGAC AAGGAGGGAA 000080
000081 GAAAGAGATT GGTgaggggg agagagagag aaagagagag agagaCACAA AGGAAGTGAG TGCAAGAGGA GCCGGCTTAG 000160
000161 CATCTAAACT catcaccacc accaccacca caaccaccTG CAGATAGATG CTCAAGTGAT TCTAGAAGAG ATCTCAAGGA 000240
000241 CTGGCGCTCT GCTCCAGTTA TGTAACCCAT GGGCTTCCCT TTGCACAGCT CCTCATGTGC TCATCTCCAT GCTGATCAAA 000320
000321 CCACCCCACC TCATTCCTTG CCTTCTGCAA GGGGAAGTGC CTCAGGCTGG AGTTTGTCCT GTCTACAGAC TGAATATGCA 000400
000401 TTTTGCCCAG TGGCTGGAGA TGTGCTGGTG GTGGAATGTG CTGGTGATTG TTTCTGGATG GAGAGCCACA GCCCCCCAGT 000480
000481 GTTCTGCCAT GACTGACTCC TGACCTTGGC AAATTGCCTC CTCTCTCCCA GCCTCCTCCA TAACAGGTGG CGATGAGTCC 000560
000561 CATTTCCTCC CTACCTCACA GGAAGGCACG CATTATAAAG GGCACACTTA TCAGATGTGC CCAGATGTGG CTGGAACTTT 000640
000641 TGGAGACAGA TACTTGGTTC ACAACTGCAA AGGTGGGCTT TCACCAGAGA AGAAAATCTC TGGGCTGCTG AGTTCAGTGG 000720
000721 GCTCCTTGCA GGCTGGTCCA GGAAGTCTGG TGTTCCTCCT GAAGGTGGCT GCTATGTCCA GCAGGTGATC AAGCTGACAG 000800
000801 TACCACAAGA ACCAAGAAAC AGAATCTGTT CCCAAGGAAT GAATGTTCTA TCTCTCTGAC CCAAAAGCAA GAGCAAGAGA 000880
000881 GAGCTGTCAC CATCATCACC CTGCTCCCAA CACAAACACA GCCCCCCAAG TCCATATTGC TGACAAGGGT ATCTGCCTTG 000960
000961 TCAGGGTGAA TCCTCTGGAC CCCAGGCCAT CCCTGGAGTG GTCAGTGCCC ACTGTGCCGG GGTTATTGTG GCCAGTCCGC 001040
001041 CTGGGTTCGC TTCTCTAAAT TTCCATGGGA TAGGAACTAT AGATCATGAA GAAGAAACAG GAACCTTGAC TCTTCACGGA 001120
001121 GGAGCCCAGG AGGTCAGAAC CATCCACCAG GAGGGTGAGC GGTAGCTGCC CAGGGCATCC CTGGAGGAAG TCGTCATACT 001200
001201 GAGGAAGAAA TTGCCAAAGC CAAGAGCTCC CAGACCTGGG CAGCTCAGGA GCTGACAGAA ACCACCCCCC AGGTCTGGAG 001280
001281 TTCAAGGGTT TTCCTCGTGG GCTGCTGGTC TGTCTCTTTC CCTTCTGGGG CAGCCGTCTC TCCTCCTTCA GCTCATTCCC 001360
001361 GTGTTCCATC TGAGGGGCGG GAGGAAGGCA GGAGGGGGAG ATGGCAGGAC CCAGACAGAT CCTCAGGACT CTCCCAGCCT 001440
001441 CTGTTGCCAT GGCAACACTG CTATTTTTAT CCCGTTGTTC ATGATGCTCA AAGCTCTAAC TTTCTCTGTT CCAGAGAGGC 001520
001521 CAGGCTGGTT TCTGCCCTCA TCCTTTAACA CAGCATCTTC TCCCAGAGGC CTGAGGATGG GAAAAAGTGA TGGAGAAAAG 001600
001601 GGGAACCCCT AAGGTCACCC CTCAGCCAGG GGGAACTGTT TAACAGGGGT TTGTCTCTGC CCTTTTGAGC CTTTGGTTTT 001680
001681 CTACCTGGCT CAGGCACCCA GGTTTATGTT TTCTAGATCA AAACTCTGCA TGGTCTCCCT GAGAGACTGG AAAAGAGCTG 001760
001761 CCAATCAGGA TGGATTTTTT CCTACACAGG TATGACACTG CAGCCACTTC CCTTCTTGGG AAAATTAAAC TTCATTCTGA 001840
001841 AGAATGTCCT GTTGGTGGTA TAAGCCAACC CCTGCCCTCC TAAAAGGGGA TAGATAATTA AATTTGGTTA ATTAGCAATC 001920
001921 AGATTCACTG GGGAATTGAA ACCAGTACTT CCCTTTCTTC TGTCCCTCCA CCAAAGAACC GGAACAAATG GCTTCATGTC 002000
002001 TTTGTCCAGT CTTTCTGCCT AAAGCAAAAT AGCATATATT CTCCAGGCTG AAAAGTAGAT TCCTCCTCAC CCCTACTCAA 002080
002081 GATGGCCACA TTTCAATCCA GGCTCTTGAA GACAGGGTCT AATGAAAGGA TTTCTGTTCT TTCTCTGTCT GTTCCCTCTG 002160
002161 GCCCAGCTTC TAGTCCTCTC CTTATGTCCC CACCTCCATG GCAGTGGCAA GAGACCCCTG AGAGTCAATG GTGCTAACGT 002240
002241 TCCCCACCTA TATACCCCTA TGTAGTTTAT CGAGATTTGA ACCCAGCACC TGGGTGGCTG TGTTGGGCGG ATACATTTCA 002320
002321 CGTCCTCAAG ACCACAACCC TGGCGACAGG TCTGGATTAA TTCTGTAAAG TAGCAATCTA TATCATGCTA AACTCCTGCA 002400
002401 CTGAGGTTCT TCCTCGGCTG AACTGACTCG TGGATGGTTA AGTTTCCTGG GGTGGCTGGA ACCCATTTAC TAAGCCTCTA 002480
002481 ATTGGTTTCA TTTTGGCTCA AGTTGCATGG TTTCCCGAAT CTATGCACCT GGAGTAAGCA CTTTTCTGGT TGCCACTGAA 002560
002561 AAGCATGCCG GCAAACGCTG CTCTGTTAAT TGCTGTAATA AACAGACTTT ATTATA
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