NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1
NALT is located in the upstream of NOTCH1, within a spacing of 10 kb..
A nuclear long noncoding RNA .
NALT promoted cell proliferation in vitro and in vivo .
NALT activated the transcription of NOTCH1..
Results provided strong evidence that the NOTCH1-dependent regulation by NALT might occurred in the stem cells in the development of T ALL .
- pediatric T cell acute lymphoblastic leukemia
Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain..
>gi|652699776|ref|NR_121577.1| Homo sapiens NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1 (NALT1), long non-coding RNA
Labs working on this lncRNA
- Department of Hematology and Oncology, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
- Yaping Wang, Peng Wu, Rufeng Lin, Liucheng Rong, Yao Xue and Yongjun Fang (2015)LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia.Scientific Reports 5:13749