MYCN opposite strand
NCYM, N-CYM, MYCN-AS1
1419902, 12880964, 19615087, 24391509
Both MYCNOS and ΔMYCN are potential inhibitors of MYCN either at the mRNA or at the protein level..
The MYCNOS:Neuroblastoma cells (NBs)carry an amplified MYCN gene are extremely malignant and MYCN-ratio in NBs is significantly correlated with both MYCN-amplification and NB-stage .
MYCN and ΔMYCN are co-regulated .
Expression of the antisense gene MYCNOS might be relevant to the progression of NB, potentially by directly inhibiting MYCN transcription by transcriptional interference at the DNA level .
The ratio of MYCNOS:MYCN expression is directly correlated with NB disease stage (p = 0.007) .
>gi|223029490|ref|NR_026766.1| Homo sapiens MYCN opposite strand (MYCNOS), transcript variant 2, long non-coding RNA
Labs working on this lncRNA
- Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Donders Institute for Brain, Cognition and Behaviour, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands.
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