MIR3936HG

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Annotated Information

Name

MIR3936HG:MIR3936 host gene

LOC553103[1]

Function

The function of LOC553103[1].

LOC553103 knockdown by specific siRNAs phenocopies the effect of EBV-miR-BART6-3p, while LOC553103 overexpression promotes cancer cell migration and invasion to facilitate EMT.[1]

Regulation

direct binding of EBV-miR-BART6-3p to lncRNA LOC553103 leads to LOC553103 expression decreased. In addition, LOC553103 is a potential target of EBV-miR-BART6-3p[1]

Expression

The expression of LOC553103[1].

LOC553103 expression is significantly repressed by EBV-miR-BART6-3p in all three cancer cell lines tested. And EBV-miR-BART6-3p inhibitors could upregulate the expression of LOC553103 in EBV-positive C666-1 cells.[1]

Sequence

>NR_110997.1 Homo sapiens MIR3936 host gene (MIR3936HG), long non-coding RNA

000001 GCGCGTGCGC GCGGGGCACC CGCCGCCGAC CAGGCAAGCC AGGCAGCAGG CGACCCAAGA CCGTCCGCGG AGGAGACAAG 000080
000081 CAAGCTGTCA TGTTATAAGC AGCCCTTTGA GGGGTCCATG TGATGTCAAG GAATGAAGTC TCTAGCCAAC ATTTAATGAG 000160
000161 GAACTGAGGC CCACCAACAA CCTTGAGTGA GCTTGGAAGT AGCTCCTTCA GCATCAGTTG GGTGTCGAGA TGACTACTGA 000240
000241 CAGCTTGACT GCAACTTCAT GAGAGTCTTC TGGACCAGAA CCACTCAAGT CAGGGTTTCC CCATGTTGGT CAGCCTGGTC 000320
000321 TCAAACTCCT GACTTCAGGT GATCCACCTG CCTCAGCCTC CCAAAGCGCT GGGATTACAG TTTCAGTTAT CTACGGCCAA 000400
000401 CTGGGTAAAC CAAATAGATG CTCTTTACAA ATATTTTTTA ACTTCTTAAA ATATCTCATT GAGGATTCCG TTCCAAGATG 000480
000481 GCCAAATAGG AACAGCTCTG GTCTGCAGCT CCCAGTGTGA TCGACGCAGA AGACGGATGA TTTCTGCATT TCCAACTGAG 000560
000561 GTACCAGTTG AATGAAGAGA AGCACACCTC CTCCCCAGAA CAGTACTGCA GCTATGATAT AACGCCTGGG CAGGGTTCGC 000640
000641 AATAGCAGCC AGGCTGTAAT GTAAGCTGGA ATTTCAATCA AGGCAGAGAG GAAACAGTTC AGATGGAGTC TTGCTCTGCT 000720
000721 GCCCAGGCTG GAGTACAGTA GTGCGATCAA GGCTCACTGG AACCTCCACC TCCTGGGTTC AAGTGATTCT CCTGCCTCAG 000800
000801 CCTCCCAAGT AGCTGGGATT ACAGCTGCCC GGACACGAAG GAGCCGAGGA GCACGCCTAC GAAGAACAGG GAGGTGGTGA 000880
000881 GGGGCACCTT CCAGTTGTCC TCACACACCA GATTCCACTG CCAAGGAAGA CAGCATGAAG CGTGAGCCCA ACCCTGAGGC 000960
000961 AGACCTCAAC CCCAGCCCAG CTCTGAGGGA ATATTAGCAC GGCTGGCGGG CAGACTCTCC TCCCCTGGGC CAGGATATTG 001040
001041 CCTTTGTACA AAGGGCATAG GCCTTGCAGC CCTGGGTTTG ACTGGCCTGT GCCGGGACTG GGGAGAGTAA CCTGGGGCAG 001120
001121 GTCACTGCCC TCCCTGAAAC TCAGGATCCT CTTTGGAAAG GGAGGGTGAT GCTCCTACTC CGCTCGCATT ACATAGCAAG 001200
001201 AAGCCAGCCA AGGCCATGGC TGTGACTGGT GACCCCTCAG CTGTGAGGCA GTCCAAAGTA AAGGTGGCAC TGCATCTTCA 001280
001281 GAAGCCAGCC TAGTGCGGAG GGGAGGTGTT TGAAAAGCCC AAAGGGCAGG GCAGAGGGCA TGGCCACTTG GTCCAGGCGT 001360
001361 AAAATTTCTT TTCCCTTGTT GAAAAGTGCA AGTGGTTCCA GGAGCTCTGT GACTTTATTT TCTGAGCAGG CCCCTCTGAG 001440
001441 AAATCATGTG GTCCCTGGTC CACTCACGCC TAGGCCAAGC TTGTGGCCTG ATTCGGGGCC CCATCGTTCT GGGGCCTACT 001520
001521 TACTCCTCTC CAGGGCTCCC TAGCTCCCCT CCTACATCCC TACACCCTCC TTCCCATCCA GTCTTTCCAG AAGTGTGGTC 001600
001601 CCTCCCATTC CCTAGGGTCT GTGGGATGCT GCTGCCCTAA CAAGTCCCTG CCAGTGCATC TACAAAATGA GTTTCAGCCA 001680
001681 GAGTTTCAGT TTGACTTAAG TCAATTAAGC AACATCTCAA GGGAGGTGAC AAAAATTTCA AAGTGTGTTT AGTGACCTTT 001760
001761 CATTTATTAA AAACAAATAA ATAAACAAAC AGATGCCAAT GA

Labs working on this lncRNA

  • The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 He B, Li W, Wu Y, Wei F, Gong Z, Bo H, Wang Y, Li X, Xiang B, Guo C, Liao Q, Chen P, Zu X, Zhou M, Ma J, Li X, Li Y, Li G, Xiong W, Zeng Z. Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103. Cell Death Dis. 2016.