MIR137HG

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MIR137HG, MIR137 host gene, a microRNA-137 functioning as a potential regulator of schizophrenia susceptibility.

Annotated Information

Approved Symbol

MIR137HG (HGNC:42871)

Approved Name

MIR137 host gene (HGNC:42871)

Chromosome

1p21.3

RefSeq ID

NR_046105

Characteristics

MIR137, transcribed as the microRNA miR-137, is one of the leading candidate schizophrenia susceptibility genes to arise from large genome-wide association studies (GWAS) of the disorder.[1] Large-scale genome-wide association studies (GWAS) have identified the chromosome 1 region containing MIR137 host gene (MIR137HG) as a susceptibility locus for schizophrenia. [2] rs1625579, within the host gene (MIR137HG) was identified as the top new associated SNP in the first large schizophrenia genome-wide association study (GWAS). [3]

Function

Evidence suggests that microRNA-137 (miR-137) is involved in the genetic basis of schizophrenia. Risk variants within the miR-137 host gene (MIR137HG) influence structural and functional brain-imaging measures, and miR-137 itself is predicted to regulate hundreds of genes. Functional studies indicate that miR-137 is involved in controlling neuronal proliferation, differentiation and dendritic arborization, all of which are important for proper neurogenesis, a process implicated in schizophrenia. RNA expression studies suggest that miR-137 regulates expression of genes involved in schizophrenia-relevant pathways as well as neuronal differentiation. Bioinformatics studies indicate that a significant number of target genes are associated with schizophrenia risk and further predict that the miRNA regulates many schizophrenia-relevant pathways.[3]

Expression

miR-137 is expressed in both the developing and adult brain, where it has been shown to play an important role in the regulation of cell proliferation and differentiation. [4]

Disease

Schizophrenia [1][3]

Ensembl ID

ENSG00000225206

Sequence

>gi|373938430|ref|NR_046105.1| Homo sapiens MIR137 host gene (MIR137HG), long non-coding RNA

000001 AGATGGTGTA GATCAGATCG ATTTGATTGC ATTAGATGAT TTTTTCCCTT CCCCACTCCT TTCTGGAAGC TCGCATCAGC 000080
000081 TGAAGGCTAT CGCCTGGGAC TCCTCGGAAG CATGAGCAAG CCGCCACCAC GCGAAGGCAC TGGGGCACAG CCAGCGCGAG 000160
000161 GCGCCGAGGT CCCTTCCCAA GGCTTGTTAA CACTGTAACC CGGCACTCGG AGAGAAGAAG CAGCTCACAC TGCCCAGAGC 000240
000241 CTACCTCACT GCACATCAGA TGACTCCCTG GCTTCTACAC ACAGTTGGAG TTCCGCTTGA AACCTGGATT TAGAGGGGTT 000320
000321 CTCTGGCCGC CATGGCACTC AATCATACCA CCTAGAGTGG ACTGGCCGAG ACCAGACTGG GTACCAAGCA GAGAAGTGCA 000400
000401 GAGGAAAGCA CTGGGAGAGC ACCAGAATTG GAAATAGAGC GGCCATTTGG ATTTGGGCAG GAAGCAGCCG AGCACAGCTT 000480
000481 TGGATCCTTC TTTAGGGAAA TCGAGTTATG GATTTATGGT CCCGGTCAAG CTCAGCCCAT CCCCAGGCAG GGGCGGGCTC 000560
000561 AGCGAGCAGC AAGAGTTCTG GTGGCGGCGG CGGCGGCAGT AGCAGCGGCA GCGGTAGCAG CGGCAGCGGT AGCAGCGGCA 000640
000641 GCGGCAGCTT GGTCCTCTGA CTCTCTTCGG TGACGGGTAT TCTTGGGTGG ATAATACGGA TTACGTTGTT ATTGCTTAAG 000720
000721 AATACGCGTA GTCGAGGAGA GTACCAGCGG CAGGGGGGCA GCGGCCGCCC TCCCCAGCCC ACCAGCTGGC CACTAAACGC 000800
000801 CCGTGGTTGC CAAGGCATCC AAAGCCTCTG GGATGTGTTC TGACTGTAAA AACTCTGATG TTGTGAAAAA AGCTTACGCT 000880
000881 TTGCCTCCAC TCAAACCAGA TGGTGTTTCG CTCTTATTGC CCAGGCTGGA GTGCAATGAC GTGATCTTGA CTCACCACAG 000960
000961 CCTCTGCATC CAGGATTCAA GCTATTCCCC TGCCTCAGCC TCCCAAAATG CTGGGATTAT AGGCGTGAGC CACCACGCCT 001040
001041 GGCCAGCATT CCCAATTTTT AAAAATGAAT GATTGGCACA AATCTTAGAA AGCCATTTTC TGTAGATTTG AAAGCAATGC 001120
001121 TATTTACATT GTTACTACTT TCTTGTTAAA TCTTGCATGT CTGCAGTATG TGTTGTAATA GAAACCTAAG ATTATGATCT 001200
001201 GCTGTATTCA TATTTGAAGA AGAAAATTTC AGACTGTATA ATCAACTAGT TGATGATTCA TATTTGCTTG TACAAAGTTA 001280
001281 AAAGTGTAAC TTGCCAGAAA AGAAGGAAGC CTGAAAAGTA TTCTAAATAC ATTAATAAGA AGGGTTCTAC ATGAATTAAT 001360
001361 TTTTGTTTTG CCATCTACAG AGTTCCTGCC ACATTCTAGG CACTTCATAT TTGCTGCAAC ATTTATTCAG ACATTGACAG 001440
001441 AACAAGAGAA ACGAAGTTAA ATTTTAAGTA CCATGGATTG AAATTAAATT TAGGGAAGAT ATTTTATAGT ATGAATTGTT 001520
001521 CATCTGTATT TAACAAGGTA TTCATTTATT TTGGGCGATT TAAGGAAGGT CCTTTCTGGA AACAGGATTA CAAACATATG 001600
001601 GACCTATTTA GTCAATTTCA ACCTTGTGAT TTTGAATCTG ACAGGTTCTC AGCTGCTTTT ATTAAATAAC GGATTTTCTT 001680
001681 AATAATTACT GTACTCAAAC TTAGCAAAAA GCTCTATTTA TAGCCCAGTT TTTTAGTCAC ACACTATTGT GTCTTGTCAA 001760
001761 ATTGAAACCA TATACTACAT TCTTTACTTA TTAAGATGGT CTTTCTTTGT AATAATTTTG GAGTAAATAG TTTACTTATC 001840
001841 TAAACCTCTG ATTTCTGATT TAACAGATTT TTGAAGCATT TATTTTCCTT ACCATACATA AAAATTGTCA GTTGAGGACA 001920
001921 AGGAAGGATT AACCTGGACT ACGGTGAATA ATTGTTCAGG TTGCTTACTG TGTAACTCCA GAGGAGCATT CACATGGTAC 002000
002001 AATTTGCAGA TTTAAGTATT TATTACAACC ATTTTCTGGC AGATAACAGT GGAACACCCT GTTCTGTTAA AATTAGTTTA 002080
002081 TTATGACAAA TTGCCTACAG ATGGACATAA ACTGTCTTGA GGAAGGGCAC CTGCTTTGGA CTGAATCGTG TCCCCCCAAA 002160
002161 ATCAAATGTT GAAGCCTAAT CTCTAATATG ATGGTATTTG GAGATGGGGC CTTTGGGAGA TAACTAGGTT TAGATGAGGT 002240
002241 CAAGAGTGTG GGGCCTTCCT GATTAGTACC CTGAAAAGAG AAAACACCAG AGAGCTTGCC CTCTCTCCCT CTTACCCCAC 002320
002321 AGGCACACAA AGAGGTCATG TGAGTACACA GTGAGATAAC AACCACCTAT GAGAAAACAG AAGAGGCTTC AGAGTGAAAT 002400
002401 CTACTTTGCT GGTACTGTAA TCTTGGACAT TATTCTCTAG AACTGTGAGA TAATAAATTT ATCTTATTT

Labs Working

  • Department of Neuroscience, Institute of Psychiatry, King's College London, London, UK
  • The Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
  • The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM USA 87106
  • Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA
  • Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
  • Department of Neurology, University of California San Francisco, San Francisco, CA, USA
  • Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland
  • Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, USA
  • KarolinskaInstitutet, Stockholm, Sweden

References

  1. 1.0 1.1 Hill MJ, Donocik JG, Nuamah RA, Mein CA, Sainz-Fuertes R & Bray NJ. Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells[J]. Schizophrenia Research. 2014, 153(1):225-230.
  2. Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia[J]. Nature genetics. 2013, 45(10):1150-1159.
  3. 3.0 3.1 3.2 Wright C, Gupta CN, Chen J, Patel V, Calhoun VD, Ehrlich S et al. Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia[J]. Translational psychiatry. 2016, 6(2):e724-e724.
  4. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells[J]. BMC medicine. 2008, 6:14-14.

Predicted Small Protein

Name MIR137HG_smProtein_515:601
Length 28
Molecular weight 3368.8299
Aromaticity 0.107142857143
Instability index 154.742857143
Isoelectric point 11.8291625977
Runs 5
Runs residual 0.0246478873239
Runs probability 0.0241300123653
Amino acid sequence MVPVKLSPSPGRGGLSEQQEFWWRRRRQ
Secondary structure LLLEEELLLLLLLLLLHHHHHHHHHHLL
PRMN -
PiMo -