MIR137HG, MIR137 host gene, a microRNA-137 functioning as a potential regulator of schizophrenia susceptibility.
MIR137 host gene (HGNC:42871)
MIR137, transcribed as the microRNA miR-137, is one of the leading candidate schizophrenia susceptibility genes to arise from large genome-wide association studies (GWAS) of the disorder. Large-scale genome-wide association studies (GWAS) have identified the chromosome 1 region containing MIR137 host gene (MIR137HG) as a susceptibility locus for schizophrenia.  rs1625579, within the host gene (MIR137HG) was identified as the top new associated SNP in the first large schizophrenia genome-wide association study (GWAS). 
Evidence suggests that microRNA-137 (miR-137) is involved in the genetic basis of schizophrenia. Risk variants within the miR-137 host gene (MIR137HG) influence structural and functional brain-imaging measures, and miR-137 itself is predicted to regulate hundreds of genes. Functional studies indicate that miR-137 is involved in controlling neuronal proliferation, differentiation and dendritic arborization, all of which are important for proper neurogenesis, a process implicated in schizophrenia. RNA expression studies suggest that miR-137 regulates expression of genes involved in schizophrenia-relevant pathways as well as neuronal differentiation. Bioinformatics studies indicate that a significant number of target genes are associated with schizophrenia risk and further predict that the miRNA regulates many schizophrenia-relevant pathways.
miR-137 is expressed in both the developing and adult brain, where it has been shown to play an important role in the regulation of cell proliferation and differentiation. 
>gi|373938430|ref|NR_046105.1| Homo sapiens MIR137 host gene (MIR137HG), long non-coding RNA
- Department of Neuroscience, Institute of Psychiatry, King's College London, London, UK
- The Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
- The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM USA 87106
- Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA
- Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
- Department of Neurology, University of California San Francisco, San Francisco, CA, USA
- Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland
- Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, USA
- KarolinskaInstitutet, Stockholm, Sweden
- Hill MJ, Donocik JG, Nuamah RA, Mein CA, Sainz-Fuertes R & Bray NJ. Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells[J]. Schizophrenia Research. 2014, 153(1):225-230.
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- Wright C, Gupta CN, Chen J, Patel V, Calhoun VD, Ehrlich S et al. Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia[J]. Translational psychiatry. 2016, 6(2):e724-e724.
- Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells[J]. BMC medicine. 2008, 6:14-14.
Predicted Small Protein
|Amino acid sequence||MVPVKLSPSPGRGGLSEQQEFWWRRRRQ|