MHENCR:melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489
MHENCR is predominantly localized in the cytoplasm of melanoma cells .
MHENCR functions as an oncogene in melanoma via activating miR-425/489-mediated PI3K-Akt pathway . MHENCR knockdown significantly inhibits melanoma cells proliferation, induces cell cycle arrest and apoptosis, and also attenuates melanoma cells migration.
MHENCR as a competitively endogenous RNA, which specifically bound to miR-425 and miR-489, can upregulate their target genes IGF1 and SPIN1 expression, and further activate PI3K-Akt pathway .
The expression of MHENCR is upregulated in melanoma tissues and further upregulated in later stage and metastatic lesions, and high expression of MHENCR is associated with poor prognosis of melanoma patients .
>NR_132417.1 Homo sapiens melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489 (MHENCR), transcript variant 1, long non-coding RNA
Labs working on this lncRNA
- Department of Burn and Plastic Surgery, The 253rd Hospital of PLA Hohhot, Inner Mongolia, China.
- Chen X, Dong H, Liu S, Yu L, Yan D, Yao X, Sun W, Han D, Gao G. Long noncoding RNA MHENCR promotes melanoma progression via regulating miR-425/489-mediated PI3K-Akt pathway. Am J Transl Res. 2017 Jan 15;9(1):90-102.